冻干重组人脑利钠肽治疗心梗合并急性心力衰竭的疗效

目的：评价冻干重组人脑利钠肽（rhBNP）治疗心肌梗死合并急性心力衰竭的安全性和有效性。方法：48例急性心肌梗死后心力衰竭患者被随机分为两组，常规治疗组（24例，给予常规治疗），rhBNP组（24例，在常规治疗的基础上加用rhBNP），观察治疗前后两组患者的各项临床指标，评价临床疗效。结果：治疗后与常规治疗组比较，rhBNP组总有效率明显提高（66．7％比91．7％），每搏量[（72．35±9．85）ml比（84．97±9．31）ml；、每分输出量[（4．49±1．52）L／min比（6．78±1．66）L／mini、左室射血分数[（44．8±8．82）％比（56．8±10．2）％]均有明显改善（P〈0．05）。结论：rhBNP能迅速改善心肌梗死合并心力衰竭患者的心功能，疗效确切，值得临床推广应用。

Therapeutic effects of Lyophilized recombinant human brain natriuretic peptide on myocardial infraction complicated acute heart failure

Objective： To evaluate safety and efficacy of Lyophilized recombinant human brain natriuretic peptide （rhBNP） in treatment of myocardial infraction complicated acute heart failure. Methods： A total of 48 patients with heart failure after acute myocardial infarction were randomly divided into routine treatment group （n = 24, received routine treatment） and rhBNP group （n = 24, received rhBNP based on routine treatment）. Clinical indexes were observed and clinical therapeutic effects were evaluated in two groups before and after treatment. Results： Com- pared with routine treatment group after treatment, there were significant increase in total effective rate （66. 7% vs. 91.7%）, stroke volume [（72.35±9.85） ml vs. （84.97 ±9.31） ml], cardiac output [- （4.49± 1.52） L/min vs. （6.78± 1.66） L/mini and left ventricular ejection fraction [ （44.8± 8.82） % vs. （56.8 ± 10.2） %] in rhBNP group, P〈0.05 all. Conclusion： The rhBNP can quickly improve heart function in patients with myocardial infarction complicated heart failure, so should be spread