儿童双侧肾母细胞瘤手术治疗的探讨

目的 总结探讨儿童双侧肾母细胞瘤综合治疗的疗效及随访结果。方法 回顾性分析我院白1998年8月至2010年8月手术治疗的双侧肾母细胞瘤患儿临床资料。结果 7例双侧肾母细胞瘤中，男性患儿3例，女性患儿4例，发病年龄最大21个月，最小6个月，平均年龄( 12.71±4.89)个月。临床表现腹部肿块7例(7/7)，血尿1例(1/6)，贫血2例(2/6)，4(4/7)例活检明确病理经术前化疗后手术，3例先手术后化疗，1例化疗2个疗程疾病进展，家属放弃治疗后死亡，5例结束整个疗程随访中，4例带瘤生存，1例随访7个月后残余肿瘤病灶消失，随访时间最长10年，最短10个月，1例术后化疗中，2年存活率85.7％。结论 儿童双侧肾母细胞瘤通过手术、化疗及放疗综合治疗，可以带瘤生存。

Surgery management of children with synchronous bilateral wilms' tumor

Objective To retrospective analysis of the results of surgery management for children with bilateral wilms' tumor. MethodsSeven patients with bilateral wilms' tumor were enrolled and follow-up from oct. 1998 to oct. 2010. ResultsThe relevant data were collected. There were 3 males and 4 females, The maximal age at diagnosis was 21 months, minimal age was 6 months, average age was 12. 71 ± 4. 89 months. Clinical symptom included abdominal mass (7/7), hematuria (1/6)and anemia (2/6). Four cases underwent operation after preoperative chemotherapy, 3 cases were give adjuvant chemotherapy after operation, 5 cases completed chemotherapy, 1 case died during chemotheraphy. Five cases were followed up, 4 lived with tumor bearing, 1 residual tumor disappeared, The maximal follow-up time was 10 year, minimal follow-up time was 10 months. Two years survival rate was 85.7 ％. ConclusionsThe patients with bilateral wilms' tumor can live with tumor bearing after standardized multidisciplinary treatment.