肝细胞癌化疗栓塞方法和肿瘤坏死

目的 评价地细胞癌肿瘤坏死与经动脉化疗栓塞（ＴＡＣＥ０方法的关系。材料与方法 观察１１７例手术观察的肝细胞癌肿块坏死和增长率，其中单纯手术５８例，４种ＴＡＣＥ后Ⅱ期手术切除５９例。结果 肝细胞癌ＴＡＣＥ后环死较自发坏死严重、范围广（Ｐ〈０．０１），坏死程度和愉体积变化与ＴＡＣＥ方法密切相关（多全塞较单材料栓塞、单纯化疗改变明显，Ｐ〈０．０１），但与ＴＡＣＥ和手术切除间期无显著相关（Ｐ〉０．０５），

The Relationship between Tumor Necrosis and Transcatheter Arter ial Chemoembolization Methods for Hepatocellular Carcinoma

Objective To study the relationship between tumor necrosis and transcatheter arterial chemoembolization (TACE) methods for hepatocellular carcinoma (HCC).Materials and Methods Tumor necrosis and volume were examined in 117 surgical specimens, including 58 cases treated with surgery alone and 59 cases treated with 4 kinds of TACE before surgery.Results Necrosis due to TACE was more severe and extensive than that seen in spontaneous cases (P<0.01). Significant difference in necrosis extent and mass volume existed between multiple material embolization and single material embolization or pure chemotherapy (P<0.01), while no relationship was found between these changes and the TACE surgery intervals (P>0.05). Necrosis severity was significantly related to the changes of the mass volume (P<0.01). Repeated TACE was more apt to cause tumor necrosis than single TACE, though no statistic significance was seen (P>0.05). In this study, total necrosis was found in 20.3% cases, only seen in the patients treated with multiple material embolization.Conclusion Repeated, multiple material embolization TACE can more easily cause necrosis and shrinkage of HCC than single treatment with one material or single chemotherapy can. An effective TACE will cause massive necrosis of the tumor within one month.