| survivin的研究进展 |
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| 引用本文： | 惠燕,黄利鸣. survivin的研究进展[J]. 肿瘤研究与临床, 2006, 18(11): 787-789 |
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| 作者姓名： | 惠燕 黄利鸣 |
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| 作者单位： | 443002,湖北,宜昌,三峡大学医学院2004级研究班 |
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| 基金项目： | 湖北省教育厅重大项目资助项目（Z200513002） |
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| 摘 要： | survivin基因是一种与肿瘤高度相关的凋亡抑制基因，其所表达的蛋白抑制细胞凋亡、促进细胞增生，同时对肿瘤患者特异性细胞免疫应答的激活和肿瘤血管的形成也有一定作用，其剪接体的问世更为它提供了崭新的研究价值。研究发现survivin复杂的功能与其在细胞中的定位表达是密切相关的。survivin剪接体的亚细胞定位和功能也在不断的探讨中。对survivin及其剪接体的作用机制和在肿瘤发生、诊断、放化疗中的作用进行了阐述。
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| 关 键 词： | survivin基因 肿瘤凋亡抑制基因 蛋白抑制细胞凋亡 细胞增生 细胞免疫应答 肿瘤血管形成 |
| 文章编号： | 1006-9801（2006）11-0787-03 |
| 收稿时间： | 2006-05-12 |
| 修稿时间： | 2006-09-15 |
The update research advances on survivin |
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| HUN Yan,HUANG Li-ming. The update research advances on survivin[J]. Cancer Research and Clinic, 2006, 18(11): 787-789 |
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| Authors: | HUN Yan HUANG Li-ming |
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| Affiliation: | The Medical College of theThree Gorges University, Sanxia 443002, China |
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| Abstract: | Studies on survivin over the past several years have shown it has significant association with cancer, its encoding protein play a important role in control of mitosis and/or apoptosis and the activity of cellullar immunologic response in cancer patients. Survivin is the finding of its splice variants make it more valuble. The multi-subcellular localization of survivin is consistent with its multiple functions in cellular metabolisms and responses. The mechanisms and the subcellular localization by which these splice variants differentially affect cancer development are unclear. This review article will update the role of survivin, and its splice variants in the mitosis/cell cycle, apoptosis, tumorigenesis, chemoprevention, drug/radiation resistance, and cancer therapeutics. |
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| Keywords: | Survivin Encoding protein Mitosis Apoptosis Cellular immunologic response |
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