梅毒血清固定与神经梅毒患者淋巴细胞亚群的检测

目的探讨梅毒治疗有效、血清固定、神经梅毒与外周血淋巴细胞(PBLC)亚群的关系。方法应用流式细胞仪检测20例梅毒治疗有效患者、23例梅毒血清固定患者、16例神经梅毒患者及20例健康人群的外周血淋巴细胞亚群。结果各组梅毒患者外周血CD4细胞(分别为29.79±5.47,31.79±6.72,33.84±8.81)、CD4/CD8比值(分别为1.34±0.46,1.54±0.70,1.62±0.67)均显著低于对照组(分别为43.50±8.93,2.20±0.43)(P<0.01);治疗有效组患者B细胞(CD19,12.26±3.43)显著高于对照组(9.00±2.04)(P<0.01),NK细胞(16.81±6.95)显著低于对照组(26.35±9.93,P<0.05);血清固定组患者NK细胞(15.82±8.44)显著低于对照组(P<0.01)。结论T淋巴细胞亚群的改变和NK细胞减少与梅毒血清固定和发展成神经梅毒推断有一定关系。

Determination of Peripheral Blood Lymphocyte Subsets in Syphilitics of Serofast and Nerosyphilis and its Significance

Objective To explore the correlation of effective treatment, serofast, neurosyphilis with peripheral blood lymphocyte subsets. Methods Peripheral blood lymphocyte subsets were measured by flow cytometry in 20 cases of effective treatment group, 23 cases of serofast group,16 cases of neurosyphilis group and 20 healthy people. Results In each group of syphilitics,the percentage of CD4 cells(were 29.79±5.47,31.79±6.72 and 33.84±8.81 respectively) and the ratio of CD4/CD8 (were 1.34±0.46,1.54±0.70 and 1.62±0.67 respectively)were significantly lower than in those of control group (were 43.50±8.93 and 2.20±0.43,P<0.01). B cells (CD19 ) in effective treatment group (12.26±3.43)were significantly higher than that in those of control group (9.00±2.04,P<0.01). NK cells in effective treatment group (16.81±6.95)were significantly lower than that in those of control group (26.35±9.93,P<0.05). NK cells in serofast group (15.82±8.44)were significantly lower than that in those of control group (P<0.01). Conclusion It is suggested that the change of T-lymphocyte subsets and the reduction of NK cells were related to serofast and neurosyphilis.