|
|||||
|
|
| 细胞外ATP和腺苷及其受体与细胞凋亡 | |
| 引用本文： | 王明霞,任雷鸣,王红芳. 细胞外ATP和腺苷及其受体与细胞凋亡[J]. 中国药理学通报, 2006, 22(9): 1029-1034 |
| 作者姓名： | 王明霞 任雷鸣 王红芳 |
| 作者单位： | 1. 河北医科大学第四医院药品科,河北,石家庄,050011 2. 河北医科大学药学院,河北,石家庄,050017 3. 河北中润制药有限公司,河北,石家庄,050011 |
| 摘 要： | 细胞外ATP(ATPo)和腺苷是细胞内外重要的信号分子,对包括肿瘤细胞在内的多种组织细胞具有细胞毒和诱导凋亡的作用。腺苷及其受体诱导细胞凋亡的机制主要涉及腺苷酸环化酶(AC)、cAMP、Ca2+等。ATP的诱导细胞凋亡作用与多个嘌呤受体有关,包括P2X1、P2X2、P2X7、P2Y1、P2Y2等,进一步的作用机制可能涉及FasL/FasR死亡受体、T细胞受体(TCR)、bcl-2和bax的基因调控等。 |
| 关 键 词： | 腺苷三磷酸,腺苷 嘌呤受体 细胞凋亡 |
| 文章编号： | 1001-1978（2006）09-1029-06 |
| 收稿时间： | 2006-05-03 |
| 修稿时间： | 2006-06-01 |
Apoptosis related with extracellular adenosine triphosphate and adenosine and their purinergic receptors |
|
| WANG Ming-xia,REN Lei-ming,WANG Hong-fang. Apoptosis related with extracellular adenosine triphosphate and adenosine and their purinergic receptors[J]. Chinese Pharmacological Bulletin, 2006, 22(9): 1029-1034 | |
| Authors: | WANG Ming-xia REN Lei-ming WANG Hong-fang |
| Affiliation: | 1. The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang 050011, China; 2. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China; 3. Zhongrun Pharmaceutical Corporation, Shijiazhuang 050011, China |
| Abstract: | Extracellular adenosine triphosphate (ATP) and adenosine are important signaling molecules in both intracellular and extracellular microenviroments of cells. They exert cytoxic and apoptotic effects in some tissues such as tumor. The proapoptotic mechanisms of adenosine and its receptors are involved in Adenylyl cyclase(AC), cAMP, Ca 2+ , etc. Apoptosis induced by ATP is as sociated with several purinergic receptors including P2X_1, P2X_2, P2X_7, P2Y_1, P2Y_2, et al, it is also involved in FasL/FasR, T cell receptor(TCR), and gene regulations of bcl-2 and bax. |
| Keywords: | adenosine triphosphate adenosine apoptosis purinergic receptors |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |