卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清IL-6的影响 |
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引用本文: | 吴仁胜,张道友,陈忠辉,杨沿浪,苏惠,高潮清,杨利才. 卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清IL-6的影响[J]. 实用药物与临床, 2008, 11(2): 65-67 |
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作者姓名: | 吴仁胜 张道友 陈忠辉 杨沿浪 苏惠 高潮清 杨利才 |
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作者单位: | 皖南医学院附属弋矶山医院肾内科,安徽,芜湖241001 |
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摘 要: | 目的探讨卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清白介素-6(IL-6)的影响,以及两药联用保护肾脏的可能机制。方法雄性SD大鼠150只,适应性喂养2周后,随机抽取18只为正常对照组(A组),另外132只制作阿霉素肾病模型。2周末,造模成功的120只随机分为4组:B组为模型对照组(n=30);C组为卡托普利治疗组(n=30);D组为洛伐他汀治疗组(n=30);E组为两药联用组(n=30)。分别于2、4、6周末,遵循随机化原则,按n=6,分层抽取各组样本,收集实验前24 h尿液及实验时的腹动脉血,所取样本置入-20℃冰箱中保存待测。结果卡托普利与洛伐他汀联用,可进一步降低血清白介素-6及胆固醇、甘油三酯浓度,减少尿蛋白,提高血浆白蛋白浓度,其疗效优于C组、D组。结论卡托普利与洛伐他汀联用可更有效地保护阿霉素大鼠肾脏功能。
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关 键 词: | 阿霉素肾病 白介素-6 卡托普利 洛伐他汀 |
Effects of combination of captopril with lovastatin on serum IL-6 in rats with Adriamycin-induced nephropathy |
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Abstract: | Objective To investigate the effects of combination of captopril with lovastatin on serum IL-6 and its likely protective mechanism.Methods 150 male Sprague-Dawlay rats were chose.After being fed 2 weeks adaptively,18 rats were divided into normal group(A,n=18) randomly,the rest 132 for making model group.At the end of 2nd week,120 adriamycin-induced nephropathy rats were divided into four groups randomly:B for exprimental control group(n=30),C for captopril treated group(n=30),D for lovstatin treated group(n=30),and E for combination of captopril with lovastatin treated group(n=30).The rats were killed at the end of 2nd,4th,6th weekend,and the samples were stratified randomly(n=6).The collected urine and abdominal aorta blood were reserved in refrigerator at-20 ℃ to be detected.Results Combination of captopril with lovastatin was more effective on inhibiting secretion of IL-6 of adriamycin-induced nephropathy rats,lowing IL-6,CHOL,TG and elevating albumin in serum than captopril or lovastatin.Conclusion Combination of captopril with lovastatin is more effective on protecting the kidney of adriamycin-induced nephropathy rats. |
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Keywords: | Adriamycin-induced nephropathy IL-6 Captopril Lovastatin |
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