卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清IL-6的影响

目的探讨卡托普利与洛伐他汀联用对阿霉素肾病大鼠血清白介素-6(IL-6)的影响,以及两药联用保护肾脏的可能机制。方法雄性SD大鼠150只,适应性喂养2周后,随机抽取18只为正常对照组(A组),另外132只制作阿霉素肾病模型。2周末,造模成功的120只随机分为4组:B组为模型对照组(n=30);C组为卡托普利治疗组(n=30);D组为洛伐他汀治疗组(n=30);E组为两药联用组(n=30)。分别于2、4、6周末,遵循随机化原则,按n=6,分层抽取各组样本,收集实验前24 h尿液及实验时的腹动脉血,所取样本置入-20℃冰箱中保存待测。结果卡托普利与洛伐他汀联用,可进一步降低血清白介素-6及胆固醇、甘油三酯浓度,减少尿蛋白,提高血浆白蛋白浓度,其疗效优于C组、D组。结论卡托普利与洛伐他汀联用可更有效地保护阿霉素大鼠肾脏功能。

Effects of combination of captopril with lovastatin on serum IL-6 in rats with Adriamycin-induced nephropathy

Objective To investigate the effects of combination of captopril with lovastatin on serum IL-6 and its likely protective mechanism.Methods 150 male Sprague-Dawlay rats were chose.After being fed 2 weeks adaptively,18 rats were divided into normal group(A,n=18) randomly,the rest 132 for making model group.At the end of 2nd week,120 adriamycin-induced nephropathy rats were divided into four groups randomly:B for exprimental control group(n=30),C for captopril treated group(n=30),D for lovstatin treated group(n=30),and E for combination of captopril with lovastatin treated group(n=30).The rats were killed at the end of 2nd,4th,6th weekend,and the samples were stratified randomly(n=6).The collected urine and abdominal aorta blood were reserved in refrigerator at-20 ℃ to be detected.Results Combination of captopril with lovastatin was more effective on inhibiting secretion of IL-6 of adriamycin-induced nephropathy rats,lowing IL-6,CHOL,TG and elevating albumin in serum than captopril or lovastatin.Conclusion Combination of captopril with lovastatin is more effective on protecting the kidney of adriamycin-induced nephropathy rats.