Chronic neutrophilic leukemia with acute myeloblastic transformation |
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Authors: | Katsuki K Shinohara K Takeda K Ariyoshi K Yamada T Kameda N Takahashi T Nawata R Shibata S Asano Y Okamura S |
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Affiliation: | Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan. |
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Abstract: | We report a rare case of chronic neutrophilic leukemia (CNL) which terminated in acute myeloblastic transformation 3 years after the onset of the disease. The increased leukocytes were mainly neutrophils at various maturational stages until 1 month before transformation without dysplastic hematopoietic cells or other myeloproliferative disorders. Repeated analyses for the Philadelphia chromosome (Ph1), rearrangement of the BCR gene or chimeric BCR/ABL mRNA, major, minor and mu, were negative. Genomic analysis of granulocyte colony-stimulating factor (G-CSF) receptor did not reveal any abnormality. The clinical manifestations were characterized by hyperleukocyte syndrome with respiratory distress and ischemic legs with gangrene. |
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