| PCNA在非霍奇金淋巴瘤中的表达及意义 |
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| 引用本文： | 刘新,陈立勇,李颖,徐功立,许洪志. PCNA在非霍奇金淋巴瘤中的表达及意义[J]. 山东医药, 2006, 46(28): 23-24 |
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| 作者姓名： | 刘新 陈立勇 李颖 徐功立 许洪志 |
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| 作者单位： | 山东省立医院,山东济南,250021;山东省立医院,山东济南,250021;山东省立医院,山东济南,250021;山东省立医院,山东济南,250021;山东省立医院,山东济南,250021 |
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| 摘 要： | 目的探讨增殖细胞核抗原（PCNA）在非霍奇金淋巴瘤中（NHL）的表达及临床意义。方法采用免疫组化SP方法检测52例NHL及12例淋巴结反应性增生（RH）患者PCNA的表达情况。结果PCNA在RH患者中的阳性表达率明显低于NHL患者；侵袭性NHL患者表达水平明显高于惰性NHL患者。乳酸脱氢酶（LDH）〈250U／L的NHL患者PCNA阳性表达率明显低于LDH〉250U／L者。PCNA阳性表达率〉25％NHL患者平均生存期较阳性表达率〈25％者短。结论PCNA与NHL的发生发展有关，并可对预后判断提供参考依据。
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| 关 键 词： | 增殖细胞核抗原 免疫组织化学 淋巴瘤 非霍奇金 |
| 文章编号： | 1002-266X（2006）28-0023-02 |
| 收稿时间： | 2006-07-20 |
| 修稿时间： | 2006-07-20 |
Significance and expression of PCNA protein in non-Hodgkin's lymphoma |
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| LIU Xin,CHEN Li-yong,LI Ying,XU Gong-li,XU Hong-zhi. Significance and expression of PCNA protein in non-Hodgkin's lymphoma[J]. Shandong Medical Journal, 2006, 46(28): 23-24 |
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| Authors: | LIU Xin CHEN Li-yong LI Ying XU Gong-li XU Hong-zhi |
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| Affiliation: | Shandong Provincial Hospital. Jinan 250021, P. R. China |
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| Abstract: | [Objective] To explore the expression of PCNA in nonHodgkin's lymphoma(NHL) cells with variable aggressiveness and its clinical significance.[Methods] SP immunohistochemistry stain method was used to detect the expression of PCNA in 52 NHL cases and 12 cases of lymph node reactive hyperplasia.[Results] The positive rate of PCNA in reactive hyperplasia of lymph node was lower than that in non-Hodgkin's lymphoma.The positive rate of PCNA was related with the aggressiveness of non-Hodgkin's lymphoma.Different PCNA expressions were found between different levels of LDH.High PCNA expression was associated with low survival time.[Conclusion] PCNA may play certain roles in the oncogenesis and progression of non-Hodgkin's lymphoma,detection of PCNA has positive effects on prognosis of non-Hodgkin's lymphoma. |
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| Keywords: | proliferating cell nuclear antigen immunohistochemistry lymphoma, non-Hodgkin |
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