| HLA-DRB1基因多态性与慢性髓性白血病的相关性研究 |
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| 引用本文： | 霍明瑞,刘海燕,于燕,郗斌,黄晓军,李丹.HLA-DRB1基因多态性与慢性髓性白血病的相关性研究[J].中国免疫学杂志,2010,26(4). |
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| 作者姓名： | 霍明瑞 刘海燕 于燕 郗斌 黄晓军 李丹 |
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| 作者单位： | 北京大学人民医院北京大学血液病研究所HLA配型室,北京,100044 |
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| 基金项目： | 教育部创新团队发展计划基金，国家高科技研究发展项目(863计划) |
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| 摘 要： | 目的:探讨HLA-DRB1等位基因多态性与慢性髓性白血病(CML)关联性。方法:采用序列特异性引物聚合酶链反应(PCR-SSP)DNA分型技术对762例慢性髓性白血病患者(男性492例,女性270例)及2 264例正常对照进行了HLA-DRB1基因分型。结果:正常人群的HLA-DRB1*15等位基因频率最高(17.25%),其次为DRB1*09(14.05%)、DRB1*12(11.73%)和DRB1*04(10.98%),DRB1*10等位基因频率最低(1.39%)。CML患者HLA-DRB1*08等位基因频率显著高于正常对照组(7.48%vs 5.39%,χ2=8.963,OR=1.023,P=0.004),男性患者的DRB1*08基因频率也明显高于正常对照(7.72%vs 5.39%,χ2=8.059,OR=1.025,P=0.007)。女性患者的DRB1*08基因频率也高于正常对照(7.04%vs 5.39%,χ2=0.115,OR=0.995,P=0.774),但没有统计学差异。结论:CML男性患者HLA-DRB1*08的表达明显高于正常人群,提示DRB1*08可能是男性CML患者的易感基因。
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| 关 键 词： | 慢性髓性白血病 基因多态性 基因频率 |
Association between HLA-DRB1 allele polymorphism and susceptibility to chronic myelogenous leukemia in Chinese Han |
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| HUO Ming-Rui,LIU Hai-Yan,YU Yan,XI Bin,HUANG Xiao-Jun,LI Dan.Association between HLA-DRB1 allele polymorphism and susceptibility to chronic myelogenous leukemia in Chinese Han[J].Chinese Journal of Immunology,2010,26(4). |
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| Authors: | HUO Ming-Rui LIU Hai-Yan YU Yan XI Bin HUANG Xiao-Jun LI Dan |
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| Institution: | HUO Ming-Rui,LIU Hai-Yan,YU Yan,XI Bin,HUANG Xiao-Jun,LI Dan.HLA Laboratory,Peking University Institute of Hematology , Peking University People Hospital,Beijing 100044,China |
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| Abstract: | Objective:The aim was to explore the association between the HLA-DRB1 allele polymorphism and susceptibility to chronic myelogenous leukemia(CML) in Chinese Han population.Methods:The polymorphism of HLA-DRB1 alleles in 762 CML patients and 2 264 normal umbilical cord blood samples were tested by polymerase chain reaction with sequence specific primer(PCR-SSP).Results:The most common allele in DRB1 locus in normal population was DRB1*15(17.25%),whereas DRB1*10 was the least frequent allele(1.39%).Compared w... |
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| Keywords: | HLA-DRB1 HLA-DRB1 gene Chronic myelogenous leukemia Genetic polymorphism Gene frequency |
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