海南地区胆石病的特点和临床流行病学调查

目的 探讨海南地区胆石病的临床流行病学特点及其影响因素。方法 对海南地区135例胆石病患者进行回顾性流行病学因素调查,对术中取得的胆石进行化学成份测定。 结果 胆管结石占51.9％,胆固醇类结石占65.9％。城镇居民、高脂饮食及肥胖者的胆囊结石发病率高,而农村居民、低脂饮食者的胆管结石发病率高。胆管结石患者的肌汁细菌培养阳性率（65.7％）高于胆囊结石患者的胆汁细菌培养阳性率（18.5％）。结论 海南地区胆石的分布部位胆囊结石与胆管结石比例接近;类型以胆固醇类结石为主。职业、生活条件、饮食习惯等因素与胆囊结石和胆管结石的发病率有关。高脂饮食及肥胖是造成胆囊结石的主要因素,而低营养、低脂饮食与胆管结石的形成有关。反复胆道细菌感染在胆管结石形成中可能起重要作用。

Clinical epidemiological investigation of gallstone disease in Hainan Province

Objective To investigate the epidemiological characteristics of gallstone disease in Haiman Province. Methods 135 patients with gallstone from September 1991 to December 1997 were analyzed retrospectively. The clinical and epidemiological data were collected, and the composition of gallstone was determined. Results 51.9% of cases wefe hepatolithiasis and cholesterol stone was about 65.7% . The incidence of gallstone was higher in city residents, obese patients and those with high lipid intake. The incidence of hepatolithiasis was higher in patients in rural areas and those with low lipid intake. Positive rate of biliary bacterial culture in hepatolithiasis paitents was significantly higher than that in gallstone paitents (65.7% vs 18.5% , P <0.05). Conclusions Proportion of hepatolithiasis and gallstone was equal, and cholesterol stone was the main type in Hainan province. The incidence of hepatolithiasis and gallstone was related with voealion, living condition, dietany habit. Frequent biliary infection may play an important role in the formation of hepatolithiasis.