高氧液预防脑卒中后抑郁的随访研究

目的探讨早期高氧液治疗对脑卒中后抑郁是否有预防作用。方法84例住院治疗的脑卒中患者随机分为研究组与对照组各42例，研究组进行常规治疗与高氧液联合治疗，对照组进行常规治疗，随访6个月。分别于入组时与随访结束时进行汉密尔顿抑郁量表（HAMD-17）、神经功能缺损程度评分（NDS）测评。结果入组时两组间HAMD-17、NDS总分相当，入组后6个月研究组HAMD-17总分、NDS总分、卒中后抑郁发生率均低于对照组。结论早期高氧液治疗可降低脑卒中后抑郁的发生率，减轻卒中后抑郁症状，促进神经功能恢复。

A follow-up study on prevention of the post-stroke depression using early high-oxygen liquid therapy

Objective To evaluate the preventive effect of early high-oxygen liquid therapy on the post-stroke depression （PSD）. Methods Eighty four patients with stroke were randomly assigned in to study group or control group, the study group treated with conventional therapy combined with highoxygen liquid, the control group treated with conventional therapy only. Hamilton rating scale for depression 17 items （HAMD-17） and Neurological impairment Degree Scale （NDS） were assessed at baseline and six-month followup. Results There was no significant difference at the total scores of HAMD-17 and NDS between study group and control group at baseline. At the end of six-month follow-up, the total scores of HAMD-17, NDS and incidence rate of PSD were lower in study group compared to control group. Conclusions Early high-oxygen liquid therapy on stroke may reduce the in eidence rate of PSD, and lighten depressive symptoms, and promote neurological function recovery.