幽门螺杆菌感染与胃部病变组织端粒酶活性相关性的研究

目的探讨胃部疾病病变组织的端粒酶活性表达与Hp感染的关系。方法用通过TRAP-银染法和幽门螺杆菌培养法检测21例胃癌（GC），35例萎缩性胃炎（AG）和38例良性胃溃疡（BGU）组织的端粒酶活性和Hp感染状况。结果胃癌、萎缩性胃炎、良性胃溃疡中端粒酶活性的分别为76．2％，48．6％，15．8％。端粒酶活性在胃癌、萎缩性胃炎标本中的表达显著高于良性胃溃疡（P〈0．01或P〈0．05）。胃癌组织中的端粒酶活性最高。Hp阳性组的端粒酶活性与Hp阴性组相比有显著性差异（P〈0．01）。结论Hp的感染引起端粒酶的活性增高，加速病变组织损伤，可能与胃癌的发生、发展具有相关性。

The effect of helicobacter pylori infection and telomerase activity on gastric diseases

Objective To investigate the relation of helicobacter pylori infection and telomerase activity on gastric diseases.Methods The activity of telomerase was detected by TRAP-sliver staining.Using culture assay were identified helicobacter pylori infections.Results The activity of telomerase were 76.2 % in gastric carcinoma(GC) group,48.6% in astrophic gastritis(AG) group,15.8% in benign gastric ulcers(BGU) group,respectively.There were significant difference of telomerase activity between GC group,AG group and BGU group(P<0.01 or P<0.05).Expression of telomerase activity in gastric carcinoma was the highest.There were significant difference of telomerase activity between Hp positive group and Hp positive group.(P<0.01).Conclusion The infection of Hp may increase telomerase activity and accelerate the demage of gastric tissue,it possibly has relation with the occurrence and development of gastric carcinoma.