| MicroRNAs在未分化甲状腺癌侵袭转移中的调控作用 |
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| 引用本文： | 王焱. MicroRNAs在未分化甲状腺癌侵袭转移中的调控作用[J]. 现代诊断与治疗, 2011, 22(2): 82-85 |
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| 作者姓名： | 王焱 |
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| 作者单位： | 泸州医学院生物化学教研室,四川,泸州,646000 |
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| 摘 要： | 上皮细胞受到细胞外因子刺激后向间质细胞转化的现象与肿瘤的侵袭转移密切相关。在此过程中上皮细胞的极性丧失、迁移和运动能力增强,同时上皮表型丢失并逐渐获得间质表型。目前的研究表明,两类微小RNA(microRNAs),即miR-200和miR-30家族的表达改变可影响未分化甲状腺癌(ATCs)的侵袭性。同时,microRNAs也可通过调控E-钙黏蛋白的表达及TGF-β信号转导通路,调节间充质-上皮转化/上皮-间充质转化(MET/EMT)过程,影响ATCs的侵袭性。
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| 关 键 词： | 微小RNA 上皮-间充质转化 未分化甲状腺癌 转化生长因子-β |
Regulating Role of MicroRNAs in the ATCs Invasion and Metastasis |
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| WANG Yan. Regulating Role of MicroRNAs in the ATCs Invasion and Metastasis[J]. Modern Diagnosis & Treatment, 2011, 22(2): 82-85 |
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| Authors: | WANG Yan |
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| Affiliation: | WANG Yan(Department of Biochemistry,Luzhou Medical College,Luzhou 646000,China) |
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| Abstract: | Epithelial-mesenchymal transition(EMT) under extrinsic stimulations is closely related to tumor invasion and metastasis.During this process,epithelial cells lose their polarity and inscreae their abilities of movement and migration while the epithelium surface get lost and gain interstitial surface gradually.By recent research studies,the expressive changes of two microRNA families,miR-200 and miR-30,could affect invasion and metastasis of anaplastic thyroid carcinomas(ATCs).Meanwhile,microRNAs also could a... |
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| Keywords: | MicroRNA EMT ATC TGF-β |
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