| 通心络胶囊对择期冠脉支架置入术患者的心肌保护作用 |
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| 引用本文： | 匡彬,杨芸. 通心络胶囊对择期冠脉支架置入术患者的心肌保护作用[J]. 现代医院, 2011, 11(5): 21-23. DOI: 10.3969/j.issn.1671-332X.2011.05.010 |
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| 作者姓名： | 匡彬 杨芸 |
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| 作者单位： | 1. 韶关市曲江区人民医院,广东韶关,512100
2. 广东省人民医院,广东广州,510080 |
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| 摘 要： | 目的通过观察在PC I术前给予通心络胶囊对术后患者的血浆脑利钠肽(BNP)、炎性介质和心肌损伤标记物的影响,进一步探讨其作用机理。方法将80例急性冠脉综合征(ACS)患者随机分为两组,实验组40例,PC I术前7 d开始给予通心络胶囊,对照组40例,PCI术前7d开始给予安慰剂。观察术前、术后血浆BNP、超敏C反应蛋白(Hs-CRP)、血清心肌肌钙蛋白Ⅰ(cTnI)、肌酸激酶同工酶(CK)-MB、血脂及术后严重心脏不良事件(MACE)。结果较之同期对照组,实验组患者术后血浆BNP、Hs-CRP、TC、TG、LDL-C、CK-MB、cTnI和MACE发生率均显著降低(p<0.05);HDL-C显著增高(p<0.05)。结论通心络胶囊可通过降低血浆BNP水平和减轻动脉粥样硬化斑块处的炎性反应来减少PC I术后的心肌损伤及MACE。
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| 关 键 词： | 通心络 经皮冠状动脉介入治疗 脑利钠肽 C反应蛋白 |
PROTECTION OF TONGXINLUO CAPSULE AGAINST MYOCARDIAL INJURY IN PATIENTS AFTER ELECTIVE PERCUTANEOUS CORONARY STENT POSTING |
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| KUANG Bin,YANG Yun. PROTECTION OF TONGXINLUO CAPSULE AGAINST MYOCARDIAL INJURY IN PATIENTS AFTER ELECTIVE PERCUTANEOUS CORONARY STENT POSTING[J]. Modern Hospital, 2011, 11(5): 21-23. DOI: 10.3969/j.issn.1671-332X.2011.05.010 |
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| Authors: | KUANG Bin YANG Yun |
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| Affiliation: | KUANG Bin,YANG Yun People's Hospital of Qujiang District,Shaoguan City,Guangdong Province 512100 PRC |
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| Abstract: | Objective By means of observing the effect of tongxinluo injection on BNP,inflammatory mediators and myocardial injury biomarkers in patients after coronary intervention(PCI) and evaluate its mechanism.Methods Eighty patients with acute coronoary syndrome(ACS) were randomly divided into two groups.Experimental group(40 cases) was treated with tongxinluo capsule since 7 days before PCI,and control group(40 cases) were not treated with tongxinluo capsule.Plasma BNP,high-sensitivity C-reactive protein(Hs-CRP),... |
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| Keywords: | Tongxinluo Percutaneous coronary intervention Brain natriuretic peptide(BNP) C-reactive protein |
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