| 葛根素注射液对骨质疏松性大鼠下颌骨骨折愈合的影响 |
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| 引用本文： | 苗波,姜龙,唐海波,张铁军,李慕勤. 葛根素注射液对骨质疏松性大鼠下颌骨骨折愈合的影响[J]. 中国体视学与图像分析, 2011, 0(2): 162-167 |
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| 作者姓名： | 苗波 姜龙 唐海波 张铁军 李慕勤 |
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| 作者单位： | 佳木斯大学附属口腔医院口腔颌面外科;黑龙江省高校生物医学材料重点实验室; |
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| 基金项目： | 黑龙江教育厅科学技术研究项目(10541232) |
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| 摘 要： | 目的研究葛根素注射液对骨质疏松性大鼠下颌骨骨折愈合的影响。方法建立WIST-AR大鼠骨质疏松模型后再在大鼠右侧下颌骨体部造成颊舌侧贯通的不完全性骨折模型,随机分为假手术+下颌骨骨折组(A),去势+下颌骨骨折+葛根素治疗组(B)和去势+下颌骨骨折+盐水对照组(C),骨折后B、C两组分别于腹腔注射葛根素注射液和盐水。于术后第1周、2周、3周和4周将每组大鼠分别随机抽取5只处死,并取右侧下颌骨,用X线片检查骨折愈合情况并测量骨折愈合处骨密度值和进行组织学观察。结果在第3周后平均骨密度分析显示B组骨折愈合处平均骨密度值均高于C组(P<0.05);差异随着愈合时间的延长而显著;组织学观察结果显示C组骨折愈合明显延迟于B组。A组和B组差别不明显。结论葛根素注射液可加快骨生长,促进骨密度增加和骨质疏松性大鼠下颌骨骨折愈合。
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| 关 键 词： | 骨质疏松 下颌骨骨折 葛根素 |
Effect of puerarin injection on the mandibular fracture healing process in osteoporotic rats |
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| MIAO Bo,JIANG Long,TANG Haibo,ZHANG Tiejun,LI Muqin. Effect of puerarin injection on the mandibular fracture healing process in osteoporotic rats[J]. Chinese Journal of Stereology and Image Analysis, 2011, 0(2): 162-167 |
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| Authors: | MIAO Bo JIANG Long TANG Haibo ZHANG Tiejun LI Muqin |
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| Affiliation: | MIAO Bo1,JIANG Long1,TANG Haibo1,ZHANG Tiejun1,LI Muqin2(1.College of Stomatology,Jiamusi University,Jiamusi 154007,China,2.Universities Key Laboratory of Biomedical Materials,Heilongjiang Province,China) |
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| Abstract: | Objective The aim of this study was to investigate the effect of puerarin injection on the mandibular fracture healing process in rats with osteoporosis.Methods WISTAR rat models of osteoporosis were established.A model of buccolingual side incomplete penetrating fracture of the right mandibular body was constructed in the osteoporotic rat models.Then the rats were divided into three groups:(A) Group of sham operation + mandibular fracture,(B) Castration + mandibular fracture + puerarin injection,(C) castra... |
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| Keywords: | osteoporosis mandibule fracture healing process puerarin injection rat |
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