巴氯芬治疗顽固性呃逆

目的 :观察巴氯芬对顽固性呃逆的疗效。方法 :80例顽固性呃逆病人分为 2组 ,其中治疗组42例 (男性 2 8例 ,女性 14例 ,年龄 48a±s 8a)采用巴氯芬治疗。最小剂量是 10mg ,bid。最大剂量为 15mg ,tid。小剂量开始 ,逐步递增。疗程 4d。3 8例对照组 (男性 2 4例 ,女性 14例 ,年龄 44a± 11a)采用氯丙嗪、苯妥英、硝苯地平、东莨菪碱等常规治疗。结果 :治疗组总有效率 98% ,对照组总有效率 5 8% (P <0 .0 5 ) ,治疗组服药d 1起效率 86% ,对照组服药d 1起效率 2 1% (P <0 .0 1) ,治疗组疗程明显缩短 (P <0 .0 1) ,不良反应少。结论 :巴氯芬是治疗顽固性呃逆较为有效的药物。

Baclofen for intractable hiccup

AIM: To assess the therapeutic effect of baclofen in treating intractable hiccup. METHODS: Eighty patients with intractable hiccup were divided into two groups. Forty two patients of treatment group (M 28, F 14; age 48 a± s 8 a) were treated with baclofen (10 mg, bid to 15 mg, tid); and started with lower doses and increase by degress for 4 d. Another 38 patients of control group (M 24, F 14; age 44 a±11 a) were conventionally treated with chlorpromazine, phenytoin, nifedipine, scopolamine etc. RESULTS: The total clinical effective rate was 98 % and 58 % respectively in the treatment group and control group ( P <0.05). The marked effective rate within 1 d was 86 % and 21 % respectively ( P <0.01). The adverse reactions were less and shorted in the treatment group ( P <0.01). CONCLUSION: Baclofen is an effective drug for treatment of intractable hiccup.