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| 毒素清颗粒对支原体肺炎老龄大鼠免疫功能和细胞因子的影响 | |
| 引用本文： | 李素云,李亚,李建生,余海滨,赵敏,余学庆,王海峰,王明航.毒素清颗粒对支原体肺炎老龄大鼠免疫功能和细胞因子的影响[J].中国实验方剂学杂志,2012,18(21):222-226. |
| 作者姓名： | 李素云 李亚 李建生 余海滨 赵敏 余学庆 王海峰 王明航 |
| 作者单位： | 1. 河南中医学院第一附属医院呼吸病研究室,郑州,450000 2. 河南中医学院第一附属医院呼吸病研究室,郑州450000;河南中医学院老年医学研究所,郑州450008 3. 河南中医学院老年医学研究所,郑州,450008 |
| 摘 要： | 目的:探讨毒素清颗粒对支原体肺炎老龄大鼠免疫功能和细胞因子的影响。方法:SD大鼠随机分为青年对照组、青年模型组,老龄对照组、老龄模型组、毒素清组和阿奇霉素组,采用气管插管法复制支原体肺炎模型。分别以毒素清(3.995 g.kg-1.d-1)、阿奇霉素(23 mg.kg-1.d-1)灌胃7 d。第8天取材,检测外周血白细胞(WBC)和中性粒细胞(NEU)计数,支气管肺泡灌洗液(BALF)支原体PCR和分泌性免疫球蛋白(sIg)A、纤维连接蛋白(FN)表达,肺脏含水量和病理,血清肿瘤坏死因子(TNF)-α、白介素(IL)-6、IL-8表达。结果:阿奇霉素组BALF肺炎支原体阳性为0例(0%),毒素清组阳性3例(30%)。青年和老龄模型组BALF中sIgA和FN分别较青年、老龄对照组显著降低(P<0.01),肺组织含水量、外周血TNF-α,IL-6,IL-8显著升高(P<0.01),且较青年模型组变化显著(P<0.01)。与老龄模型组比较,毒素清组和阿奇霉素组sIgA,FN显著升高(P<0.01),肺组织含水量、TNF-α,IL-6,IL-8显著降低(P<0.01);毒素清组BALF中sIgA明显高于阿奇霉素组(P<0.01),IL-8低于阿奇霉素组(P<0.05)。结论:毒素清对老龄大鼠支原体肺炎作用明显,其机制可能与增强免疫功能、降低炎症因子表达,减轻炎症反应有关。 |
| 关 键 词： | 支原体肺炎 免疫功能 细胞因子 毒素清颗粒 |
| 收稿时间： | 3/6/2012 12:00:00 AM |
Effect of Dusuqing Granule on Immune Function and Cytokines in Aged Rats with Mycoplasma Pneumonia |
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| LI Su-yun,LI Y,LI Jian-sheng,YU Hai-bin,ZHAO Min,YU Xue-qing,WANG Hai-feng and WANG Ming-hang.Effect of Dusuqing Granule on Immune Function and Cytokines in Aged Rats with Mycoplasma Pneumonia[J].China Journal of Experimental Traditional Medical Formulae,2012,18(21):222-226. | |
| Authors: | LI Su-yun LI Y LI Jian-sheng YU Hai-bin ZHAO Min YU Xue-qing WANG Hai-feng and WANG Ming-hang |
| Institution: | Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China;Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China;Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China;Institute of Gerontology, Henan University of TCM, Zhengzhou 450008, China;Institute of Gerontology, Henan University of TCM, Zhengzhou 450008, China;Institute of Gerontology, Henan University of TCM, Zhengzhou 450008, China;Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China;Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China;Institute of Respiratory Disease, First Affiliated Hospital of Henan University of Traditional Chinese Medicine(TCM), Zhengzhou 450000, China |
| Abstract: | |
| Keywords: | Mycoplasma pneumonia immune function cytokine Dusuqing granule |
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