慢性乙型肝炎外周血HBV-LHBs反式激活功能与抗病毒疗效关系的研究

目的 探究慢性乙型肝炎患者血清中乙型肝炎病毒外膜大蛋白分子(HBV-LHBs)反式激活功能与慢性乙型肝炎抗病毒治疗疗效关系.方法 对60例抗病毒治疗的慢性乙型肝炎患者采取每3个月进行HBV DNA、HBV-LHBs以及乙肝免疫标志物检测观察各指标间的变化.结果 入组时60例抗病毒组HBV DNA与HBV-LHBs检出率有较高的一致性检出结果,无统计学意义(P＞0.05),HBV-LHBs阳性率与HBeAg阳性率存在差异(X2=4.08,P＜0.05).经过24个月抗病毒治疗HBV-LHBs始终表达者29例,其中HBV DNA在24个月里出现转阴后反弹的20例、HBV DNA持续阳性未转阴者7例.60例患者24个月里未发现HBsAg血清转换,4例出现HBeAg血清转换.结论 (1)血清HBV-LHBs检测能够反映出乙肝病毒的复制情况与HBVDNA具有较好的相关性.(2)抗病毒治疗过程中动态观察HBV-LHBs的表达能够预测抗病毒治疗的有效性.

Detection of peripheral blood HBV-LHBS transactivation function and its relationship with anti-viral efficacy

Objective Explore the serum of patients with CHB of HBV large envelope protein(HBVLHBs)trans-activation funotion and antiviral therapy effect relationship.Methotis 60 cases of anti-viral treatment of patients with chronic hepatitis B to take every 3 months HBVDNA,HBV-LHBs.as well as detection of hepatitis B immune markers to observe the changes in indexes.Results Income group 60 cases of anti-virus group HBVDNA with HBV-LHBs have a higher detection rate of the consistency of the results found no statistical significance(P＞0.05),HBV-LHBs-positive rate and positive rate of HBeAg differences(X2=4.08,P＜0.05).After 24 months of antiviral therapy HBV-LHBs expression always HBVDNA in 29 cases of which occurred 24 months after the negative reaction of the 20 cases.continuous positive were seven cases of non-negative.60 cases of patients 24 mortths found no HBsAg seroconversion,four cases of emergence of HBeAg seroconversion.Conclusion(1)detection of serum HBV-LHBs to reflect the hepatitis B virus replication with HBVDNA good correlation.(2)anti-viral treatment of dynamic observation of the process of HBV-LHBs expression Can predict the effectiveness of anti-viral therapy.