| 防治成人呼吸窘迫综合征的人工重组肺泡表面活性剂研制II.生物发光法筛选制剂处方 |
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| 引用本文： | 江志强,胡天喜,马远鸣,奚念朱.防治成人呼吸窘迫综合征的人工重组肺泡表面活性剂研制II.生物发光法筛选制剂处方[J].药学学报,1997,32(2):123-126. |
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| 作者姓名： | 江志强 胡天喜 马远鸣 奚念朱 |
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| 作者单位： | 上海医科大学药学院生物药剂学研究室,上海200032;*华东师范大学生物系,上海200062;**上海医科大学药学院靶向制剂室 |
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| 摘 要： | 在前期用表面化学方法进行防治成人呼吸窘迫综合征的药物制剂处方筛选基础上,通过建立尘肺动物模型,用生物发光技术从清除自由基能力角度对制剂进行处方筛选,获到了有良好表面性能和一定自由基清除能力的人工重组肺泡表面活性剂制剂处方。该制剂有待经模型动物防治试验评价。
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| 关 键 词： | 成人呼吸窘迫综合征(ARDS) 生物发光法 尘肺动物模型(SD鼠) 人工重组肺泡表面活性剂 |
| 收稿时间： | 1996-03-20 |
Artificial reconstituted pulmonary surfactant used for prevention and treatment of adult respiratory distress syndrome. II. Bioluminescence method for optimizing formulation] |
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| ZQ Jiang,YM Maand NZ Xi.Artificial reconstituted pulmonary surfactant used for prevention and treatment of adult respiratory distress syndrome. II. Bioluminescence method for optimizing formulation][J].Acta Pharmaceutica Sinica,1997,32(2):123-126. |
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| Authors: | ZQ Jiang YM Maand NZ Xi |
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| Institution: | Division of Biopharmaceutics, School of Pharmacy, Shanghai Medical University (SMU), Shanghai 200032. |
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| Abstract: | Based on optimizing the formulations of artificial reconstituted pulmonary surfactant (APS) used for the prevention and treatment of adult respiratory distress syndrome (ARDS) by a surface chemical method, a quartz lung animal model to obtain active alveolar macrophages (AMs) was established, using a bioluminescence technique to optimize APS's formulation according to the free-radical-scavenging abilities of APS. An optimal formulation was obtained, which showed good surface properties and free-radical-scavenging abilities. The APS preparation will be used in ARDS animal model test. |
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| Keywords: | Bioluminescence method Quartz lung animal model(SD rat) Artificial reconstituted pulmonary surfactant Adult respiratory distress syndrome(ARDS) |
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