母牛分枝杆菌菌苗对复治性肺结核的辅助治疗作用

目的观察母牛分枝杆菌菌苗（微卡）在复治性肺结核治疗中的疗效。方法将146例痰抗酸杆菌（AFB）阳性复治肺结核患者分成微卡治疗组（n：90）和对照组（n=56）疗程各6个月，前者采用复治化疗方案加用微卡治疗，后者仪用复治方案治疗。结果疗程结束时微卡治疗组和对照组痰阴转率分别为85．56％（77／90）、67．86％（38／56），差异有显著性（P〈0．05）。微卡治疗组和对照组有效率分别为81．11％（73／90）、44．64％（25／56），两组比较差异有显著性（P〈0．001）。结论微卡能改善难治性肺结核患者的细胞免疫功能，有助于痰菌阴转和病灶吸收，可作为复治性肺结核化疗的辅助药物。

Analysis of therapeutic effects of Mycobacterium vaccae on multi-drug resistant pulmonary tuberculosis

Objectives To assess the effects of Mycobacterium vaccae in treating multi-drug resistant (MDR) pulmonary tuberculosis. Methods 146 cases of MDR pulmonary tuberculosis with bacteriological sputum being positive were divided into immunotherapy group(n=90) and control group(n=56). The former group was treated by chemotherapy and M.vaccae for consecutive 6 months, whereas the latter was treated by chemotherapy only for 6 months. Results After the 6-month treatment, the sputum negative conversion rates for the immunotherapy group and for the chemotherapy-only group were, respectively, 85.56% (77/90) and 44.64% (25/56): P<0.05. The effective rates for the immunotherapy group and for the chemotherapy-only group were, respectively, 81.11%(73/90)and 44.64%(25/56): P<0.001. Conclusions M.vaccae, as a supplement to chemotherapy, has a beneficial effect on the treatment of MDR pulmonary tuberculosis by improving the cell-medicated immunity, sputum negative conversion and X-ray manifestations.