| 血管内穿线法制作大鼠蛛网膜下腔出血模型 |
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| 引用本文： | 赵沃华,朱贤立,赵洪洋. 血管内穿线法制作大鼠蛛网膜下腔出血模型[J]. 中国临床神经外科杂志, 2002, 7(1): 42-43 |
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| 作者姓名： | 赵沃华 朱贤立 赵洪洋 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院神经外科,武汉,430022 |
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| 摘 要： | 目的 建立一种不开颅的大鼠蛛网膜下腔出血模型。方法 从大鼠颈内动脉颈段穿入尼龙线至颅内,分别观察尼龙线入颅部位、颅内有无蛛网膜下腔出血并行病理切片检查。结果 实验组有明显的蛛网膜下腔出血形成。结论 血管内穿线法可以制作确切的大鼠蛛网膜下腔出血模型,特别适用于蛛网膜下腔出血急性期脑细胞损害的研究。
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| 关 键 词： | 蛛网膜下腔出血 动物模型 大鼠 |
| 文章编号： | 1009-153X(2002)01-0042-02 |
| 修稿时间： | 2000-02-25 |
A Model of Subarachnoid Hemorrhage Produced by Artificial Endovascular Perforation in Rats |
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| ZHAO Wo-hua,ZHU Xian-li,ZHAO Hong-yang. A Model of Subarachnoid Hemorrhage Produced by Artificial Endovascular Perforation in Rats[J]. Chinese Journal of Clinical Neurosurgery, 2002, 7(1): 42-43 |
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| Authors: | ZHAO Wo-hua ZHU Xian-li ZHAO Hong-yang |
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| Affiliation: | ZHAO Wo-hua,ZHU Xian-li,ZHAO Hong-yang. Department of Neurosurgery,Xiehe Hospital,Tongji Medical School,Huazhong University of Technology and Science,Wuhan 430022 |
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| Abstract: | Objective To establish a new model of subarachnoid hemorrhage (SAH) in rats. Methods SAH was produced by making a nylon thread pass through the right internal carotid artery and pierce its bifurcation. SAH was confirmed by postmortem examination. Result SAH was produced in all the rats received the above-mentioned procedures. Conclusions The technique presented here for establishing a noncraniotomy SAH model is reliable. It is particularly suitable for study of the acute pathological changes of the brain induced by SAH. The advantages and disadvantages of this SAH model deserve further studies. |
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| Keywords: | Subarachnoid hemorrhage Animal model Rats |
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