Breakage of B cell tolerance and autoantibody production in anti-erythrocyte transgenic mice

In summary, there are two pathways for activation of peritoneal B-1 cells in HL mice: T cell-dependent and T cell-independent pathways. In both pathways, IL-10 is suggested to play an important role (Fig. 1). We have not yet known what type of cells secrete IL-10 by and whether other soluble factors are involved in each pathway. These questions are to be elucidated by further studies on HL mice.