奎硫平治疗精神分裂症患者的疗效及生活质量影响

目的:探讨奎硫平与氯丙嗪对精神分裂症患者的疗效及生活质量的影响。方法:对62例精神分裂症患者,随机使用奎硫平和氯丙嗪治疗,疗程3个月。采用阳性与阴性症状量表(PANSS)评定疗效,采用治疗中出现的症状量表(TESS)评定不良反应,以生活质量综合评定问卷(GQOLI-74)评定生活质量。结果:两组均有显著疗效,奎硫平可显著提高生活质量。两组间无显著差异(P>0.05)。氯丙嗪组不良反应比奎硫平组多。结论:奎硫平和氯丙嗪对精神分裂症疗效相当,奎硫平不良反应较少,对提高患者生活质量的效果明显优于氯丙嗪。

Quetiapine treatment in schizophrenia curative effect and quality of life

Objective:To investigate the efficacy and quality of life in schizophrenic patients treated by quetiapine or chlorpromazine Method:62 patients with schizophrenia were randomly divided into quetiapine group and chlorpromazine group for 3 months treatment.Positive and negative syndrome scale(PANSS)was used to evaluate the clinical efficacy,treatment emergent symptom scale(TESS)for adverse effect and general quality of life inventory(GQOLI-74)for quality of life.Results:The patients in both groups had significant clinical efficacy,with queiepine obviously improving the quality of life and chlorpromazine having more adverse effects compared with quetiapine.Conclusion:Quatiepine and chlorpromazine are similar in the treatment of schizophrenia.However,compared with chlorpromazine,quetiapine has less adverse effects and can improve schizophrenic patients' quality of life.