生存素与皮肤肿瘤相关性的研究进展

生存素基因是凋亡抑制蛋白家族新成员,因其结构较为独特,且能选择性地在肿瘤中表达,正常终末分化组织中不表达,是皮肤鳞癌、恶性黑素瘤的预后指标;抑制其表达能显著促进常见皮肤恶性肿瘤细胞发生凋亡,对正常组织无明显影响,有望成为肿瘤标记物和肿瘤治疗的新靶点。

Relationship Between Survivin and Cutaneous Tumors

Survivin is a novel member of the inhibitor of apoptosis protein families. Because of its special structure and distribution, that is, it only expresses in tumor tissues and cannot be found in normal terminally differentiated tissues, survivin is an indicator of prognosis for skin squamous cell carcinoma and malignant melanoma. Furthermore, the inhibition of its expression can induce the apoptosis of malignant tumor cells significantly, and has no impact on normal tissues. It is hopeful for survivin to become a valuable mark and a new therapeutic target of tumors.