| 丹参对急性坏死性胰腺炎肾脏损害的干预作用 |
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| 引用本文： | 吴建农,张建新,刘敏,孙亚军. 丹参对急性坏死性胰腺炎肾脏损害的干预作用[J]. 江苏大学学报(医学版), 2004, 14(6): 500-501 |
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| 作者姓名： | 吴建农 张建新 刘敏 孙亚军 |
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| 作者单位： | 江苏大学附属医院,病理科,江苏,镇江,212001;江苏大学附属医院,普外科,江苏,镇江,212001;江苏大学附属医院,病理科,江苏,镇江,212001;江苏大学附属医院,普外科,江苏,镇江,212001;江苏大学附属医院,病理科,江苏,镇江,212001;江苏大学附属医院,普外科,江苏,镇江,212001;江苏大学附属医院,病理科,江苏,镇江,212001;江苏大学附属医院,普外科,江苏,镇江,212001 |
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| 摘 要： | 目的探讨丹参对急性坏死性胰腺炎(acutenecrotizingpancreatitis,ANP)肾损害的干预作用。方法SD大鼠96只,随机分为对照组(C)、胰腺炎组(P)和治疗组(T)。5%牛磺胆酸钠胰腺被膜下均匀注射,制作ANP模型[1]。观察制模后2h及12h各组肾组织中性粒细胞浸润情况及肾功能和肾组织学改变。结果与C组对比,P组在制模后2h及12h肾组织学损害及肾组织中白细胞浸润明显增加(P<0001)。与P组对比,制模后2hT组肾组织中中性粒细胞减少(P<0001),12h后肾组织中性粒细胞浸润明显减少(P<0001),2h及12h肾组织学损害均明显减轻(P<005)。结论丹参对ANP肾损害具有一定的干预作用。
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| 关 键 词： | 胰腺炎 肾损害 丹参 |
| 文章编号： | 1671-7783(2004)06-0500-03 |
| 修稿时间： | 2004-05-31 |
The Effect of Iabiatae on Renal Injury in Rats with Acute Necrotizing Pancreatitis |
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| WU Jian-nong,ZHANG Jian-xin,LIU Min,SUN Ya-jun. The Effect of Iabiatae on Renal Injury in Rats with Acute Necrotizing Pancreatitis[J]. Journal of Jiangsu University Medicine Edition, 2004, 14(6): 500-501 |
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| Authors: | WU Jian-nong ZHANG Jian-xin LIU Min SUN Ya-jun |
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| Abstract: | Objective: To explore the effects of labiatae on the changes of renal injury in rats with acute necrotizing pancreatiais(ANP). Methods: A total of 96 rats were randomly divided into control group (C),pancreatitis group (P) and treatment group (T). The model of ANP was established by injection of 5% sodium taurocholate into the pancreatic capsule. The number of neutrophils infiltrating in the kidney and the pathological changes were observed at 2 h and 12 h after induction of ANP. Results: Comparing with group C, the renal pathological changes and the neutrophils infiltration in the kidney were significant at 2 h and 12 h after ANP in group P (P<0.001). Contrast with group P, the renal pathological changes and neutrophils infiltration were alleviated significantly(P<0.05) at 2 h and 12 h in group T. Conclusion: The labiatae had the effects on protecting the ANP renal injury. [ |
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| Keywords: | Pancreatitis Kidney injury Labiatae |
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