慢性荨麻疹患者的甲状腺功能及自身抗体水平分析

目的：检测甲状腺功能和自身抗体与慢性荨麻疹发病及病情严重性的相关性。方法：收集91例慢性荨麻疹患者和78例健康志愿者的临床资料，用直接化学发光法测定血清中慢性荨麻疹患者及健康志愿者甲状腺功能及TGAb、TPOAb自身抗体。结果：慢性荨麻疹患者甲状腺自身抗体阳性率分别为13.19%及15.38%，明显高于健康对照组的2.56%及10.26%，差异有统计学意义（P <0.05）。甲状腺功能异常者较功能正常者风团每日发作频率高（P <0.05）。结论：甲状腺自身免疫的异常可能与慢性荨麻疹的发病有关，甲状腺功能可能与慢性荨麻疹的发作频率相关

Analysis of thyroid function and autoantibodies in the patients with chronic urticaria

Objective:To detect thyroid function and autoantibodies, and to determine their relationship with chronic urticaria. Methods:Clinical data were collected, and thyroid function, autoantibody and TGAb/TPOAb were detected with direct chemical luminescence in 91 patients with chronic urticaria and 78 healthy donors. Results:The positivity rates of TGAb and TPOAb and/or TGAb thyroid autoantibody in the patients with chronic urticaria was 13.19% and 21.98%, which was higher than those in the control group (2.56% and 10.26%), with a significant difference (P<0.05). The episodes of wheals in the patients with thyroid dys￣function was higher than those with euthyroidism ( P<0.05) . Conclusion:Thyroid autoimmunity may be relat￣ed to the pathogenesis of chronic urticaria,while thyroid function may be associated with the severity of the dis￣ease.