关节病型银屑病与强直性脊柱炎易感基因关联研究

目的：对关节病型银屑病与强直性脊柱炎的易感基因进行关联分析，以期发现共同的易感基因。方法：以379例关节病型银屑病（PsA）、595例寻常型银屑病（PsV）及806例健康对照为样本，以Sequenom MassARRAY 系统为平台，对全基因组关联研究发现的强直性脊柱炎的9个易感基因SNP位点进行基因分型和数据分析。结果：ERAP1基因（rs27037，P=6.66×10-5，OR：1.43）、21q22.2（rs2242944，P =1.07×10-3, OR：0.73）及IL23R基因（rs1004819，P=4.58×10-3，OR：1.28）与PsA相关。ERAP1（ rs27037， P=1.56×10-4，OR：1.35）与PsV相关。ERAP1基因对于PsA和PsV的患病风险无差异。IL23R基因(rs1004819)及21q22.2（rs2242944）在PsA和PsV患病风险上存在中等程度的异质性（I2值分别为57.41和71.20），但P值无明显差异（小于0.05）。 IL23R基因（rs11209032，p=1.57×10-3，OR:1.52）与PsA脊柱炎相关。结论：ERAP1基因、21q22.2区域及IL23R基因是PsA与强直性脊柱炎共有的易感基因。

Susceptibility loci of ankylosing spondylitis in patients with psoriatic arthritis

Objective:To determine the susceptibility loci of ankylosing spondylitis found by GWAS in pa￣tients with psoriatic arthritis ( PsA) . Methods:Nine susceptibility SNPs of ankylosing spondylitis were geno￣typed in 379 patients with PsA, 595 patients with psoriasis vulgaris ( PsV) and 806 healthy controls by Se￣quenom MassARRAY. Results: ERAP1 ( rs27037, P = 6. 66 × 10-5 , OR:1. 43 ) , chromosome 21q22. 2 (rs2242944, P=1.07×10-3, OR:0.73)and IL23R (rs1004819, P=4.58×10-3,OR:1.28)were significant association with susceptibility of PsA. ERAP1 (rs27037, P=1.56×10-4,OR:1.35) associated with PsV. There was no heterogeneity of ERAP1( rs27037) between PsA and PsV groups and there was a heterogeneity of chromosome 21q22.2 ( rs2242944) and IL23R ( rs1004819) between them. IL23R( rs11209032) was found to be associated with axial PsA (P=1.57×10-3,OR:1.52). Conclusion: ERAP1, 21q22.2 domain and IL23R are common susceptibility genes of both PsA and ankylosing spondylitis.