NB-UVB联合8-MOP PUVA治疗小腿斑块状银屑病疗效评价

目的: 评价NB-UVB联合8-甲氧补骨脂素（8-MOP） PUVA治疗斑块状银屑病的疗效。方法: 分别对16例银屑病患者双侧小腿进行PASI评分，一侧给予NB-UVB照射，另一侧给予NB-UVB联合8-MOP PUVA，每周3次，共治疗20次。结果: NB-UVB治疗侧治疗前后PASI评分分别为8.21±2.97和2.31±1.01，差异有统计学意义(P＜0.05)；NBUVB联合8-MOP PUVA治疗侧分别为8.33±2.54和1.20±0.93，差异有统计学意义(P＜0.05)。治疗后NBUVB联合8-MOP 治疗侧较NB-UVB治疗侧PASI更低,差异有统计学意义(P＜0.05)。结论：NB-UVB联合8-MOP PUVA可明显促进小腿顽固部位皮损的消退。

Efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris

Objective:To assess the efficacy of NB-UVB combined with 8-MOP PUVA in the treatment of psoriasis vulgaris on lower legs. Methods:The PASI of lesions on lower legs of 16 patients was assessed. One side of the lower legs of the patients was treated with NB-UVB and another side was treated with NB-UVB combined with PUVA, three times a week, 20 times totally. Results:The PASI of the lesions treated with NB-UVB before and after treatment were 8.21±2.97 and 2.31±1.01, with significant difference (P<0.05) and the lesion treated with NB-UVB combined with PUVA were 8. 33 ± 2. 54 and 1. 20 ± 0. 93, with a significant difference ( P<0.05) . The PASI of the lesions treated with NB-UVB combined with PUVA was lower than that of the lesion treated with NB-UVB alone, with a significant difference (P<0.05) . Conclusion: NB-UVB combined with PUVA is more effective than NB-UVB alone in the treatment of psoriatic plaque on legs.