Caspase-3 和Caspase-8与扁平苔藓的研究进展

Caspase-3和Caspase-8作为含半胱氨酸的天冬氨酸蛋白水解酶家族成员，是参与细胞凋亡过程的两个重要蛋白。Caspase-8是重要的凋亡启动蛋白，可通过多种途径介导凋亡反应的发生，Caspase-3作为凋亡过程中的执行者，活化后可以加速细胞凋亡的发生。最新研究发现Caspase-3和Caspase-8在扁平苔藓皮损处(特别是基底层处)高表达，表明两者可能参与了扁平苔藓的凋亡过程，并导致了本病的病理变化。

Update of the Caspase-3 and Caspase-8 in lichen planus

Caspase-3 and Caspase-8 are important proteins in the process of apoptosis. Caspase-8 can start apoptotic reaction which can mediate apoptosis in a variety of ways. Caspase-3 can accelerate cell apop-tosis after activation. The new studies reported high expression of Caspase-3, Caspase-8 in lichen planus le-sions, especially in the basal layer which showed that Caspase-3, Caspase-8 might be involved in the apop-totic response process of lichen planus.