CD4~+CD25~+调节性T细胞与Th17细胞在寻常型银屑病中的表达 |
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引用本文: | 张玉丽,王逸飞,张春敏. CD4~+CD25~+调节性T细胞与Th17细胞在寻常型银屑病中的表达[J]. 中国麻风皮肤病杂志, 2016, 0(11): 653-656 |
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作者姓名: | 张玉丽 王逸飞 张春敏 |
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作者单位: | 1. 聊城市人民医院 山东聊城,252000;2. 山东大学医学院,山东济南,250014;3. 山东大学第二医院,山东济南,250033 |
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摘 要: | 目的:检测外周血中CD4~+CD25~+调节性T细胞(简称Treg细胞)与Th17细胞在寻常型银屑病(PV)中的表达。方法:34例寻常型银屑病患者,18例正常人作为对照。采用流式细胞术检测外周血中Treg细胞、FOXP3~+Treg细胞及Th17细胞的表达水平。结果:PV患者外周血中Treg细胞比例和FOXP3~+Treg细胞比例分别为(3.68±1.22)%和(0.53±0.19)%,低于正常对照组的(6.63±1.00)%和(0.76±0.14)%(P0.05)。Th17细胞比例为(2.20±0.78)%,高于正常对照组的(0.65±0.22)%(P0.05)。PV患者外周血中Treg细胞的表达与FOXP3~+Treg细胞的表达呈正相关(r=0.563,P0.05),而Treg细胞的表达与Th17细胞的表达呈负相关(r=-0.522,P0.05);Treg细胞和Th17细胞二者与PASI评分无相关性,与病程亦无相关性。结论:Treg细胞表达的减少及Th17细胞应答的增强,可能是导致PV免疫失衡的重要原因。
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关 键 词: | 寻常型银屑病 CD4%2BCD25%2B调节性T细胞 Th17细胞 Foxp3 PASI评分 流式细胞术 |
Role of CD4+CD25+ regulatory T cells and Th17 cells in patients with psoriasis vulgaris |
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Abstract: | Objective:To detect the expression of Treg cells and Th17 cells in the patients with psoriasis vulgaris ( PV) . Methods:Thirty-four PV and 18 healthy controls were enrolled in the study, and Treg cells, Foxp3 and Th17 cells of the blood were detected by flow cytometry. Results:The percentage of Treg cells and Foxp3 cells were (3.68±1.22)% and (0.53±0.19)%, which were significantly lower than those in normal controls (6.63±1.00)%, and (0.76±0.14)% (P<0.05). The percentage of Th17 cells was (2.20±0.78)%, which was significantly higher than that in normal controls (0.65±0.22)% (P<0.05). The expression of Treg cells and FOXP3+Treg cells was positively correlated (r=0.563,P<0.05), but the expression of Treg cells and Th17 cells was negatively correlated (r=-0.522, P<0.05). The correlationa mong Treg cells, Th17 cells, PASI score and duration of the disease was not significant ( P>0.05) . Conclusion:The decrease in the expression of Treg cells and the increased response of Th17 cells may be the important factors for the immuno-logical imbalance in PV. |
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Keywords: | psoriasis vulgaris regulatory T cells Th17 cells FOXP3 PASI score flow cytometry |
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