慢性自发性荨麻疹维生素D和部分急性时相反应物的检测

目的：明确维生素D与超敏C反应蛋白(CRP)、补体C3、C4水平和慢性自发性荨麻疹(CSU)严重程度的关系。方法：检测50例CSU患者和30名健康对照者25( OH) D和超敏C反应蛋白(CRP)、补体C3、C4水平,并对患者进行病情严重程度评分（UAS7）。结果：CSU组25( OH) D血清浓度明显低于健康对照组，CSU患者CRP、C3、C4水平明显高于健康对照组。25( OH) D血清浓度与UAS7评分呈负相关，与CRP、C3、C4之间无明显相关性。结论：维生素D的水平与慢性荨麻疹病情相关。

Detection of the levels of vitamin D and some acute phase response pattern in the patients with chronic spontaneous urticaria

Objective:To determine the relationship among vitamin D level, and C3, C4 and CRP con-centrations and the disease severity of chronic spontaneous urticaria. Methods: Concentrations of CRP, C3, C4 and 25-hydroxyvitamin D [ 25( OH) D] were detected in 50 patients and 30 healthy controls. The disease severity score ( UAS7) was assessed clinically. Results:The level of serum 25( OH) D in CSU patients was significantly lower than that in controls and the concentrations of CRP , C3 and C4 were significantly higher than those in controls. There was a negative correlation between the level of 25( OH) D and UAS7 score in the patients and there was no correlation between the levels of 25(OH) D, and the concentration of CRP, C3 and C4. Conclusion:The serum level of 25( OH) D is associated with the severity of CSU.