XIAP和caspase-9在尖锐湿疣组织中的表达

目的：检测XIAP和caspase-9在CA组织中的表达。方法：采用免疫组化方法分别检测72例CA组织和20例正常包皮组织中XIAP和caspase-9蛋白的表达。结果：CA组织中XIAP蛋白的阳性表达率（56.94％）高于对照组（15.00％），其差别有统计学意义（P＜0.05）；而caspase-9蛋白的阳性表达率（37.50％）较对照组（70.00％）低，其差别亦有统计学意义（P＜0.05）。两种蛋白在CA组织中的表达呈负相关(r=-0.83，P＜0.05)。结论：XIAP抑制caspase-9的活性和表达，两者共同参与CA的发病过程。

The expression of XIAP and caspase-9 in condyloma acuminatum

Objective:To detect the expression of XIAP and caspase-9 in condyloma acuminatum. Meth￣ods:The immunohistochemistry method was used to detect the expression of XIAP and caspase-9 in the tis￣sues of 72 patients with condyloma acuminatum and prepuce tissues of 20 healthy persons. Results:The posi￣tive rate of XIAP protein in condyloma acuminatum was significantly higher than that in normal prepuces ( 56.94% vs 15%, P<0.05) , while the positive rate of caspase-9 protein in condyloma acuminatum was lower than that in normal prepuces (37.5% vs 70%, P<0.05). There was a negative correlation between the expres￣sion of XIAP and caspase-9 ( r=-0.83 P<0.05) . Conclusion:XIAP may promote the development of condy￣loma acuminatum by inhibiting the activity of caspase-9. The abnormal expression of XIAP and caspase-9 may be involved in the progression of condyloma acuminatum.