| 真核细胞翻译起始因子4E在皮肤基底细胞癌中的表达 |
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| 引用本文： | 邓越,刘海东,庄乐,马伟元. 真核细胞翻译起始因子4E在皮肤基底细胞癌中的表达[J]. 中国麻风皮肤病杂志, 2016, 32(7): 388-390 |
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| 作者姓名： | 邓越 刘海东 庄乐 马伟元 |
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| 作者单位： | 山东大学齐鲁医院皮肤科，济南，250012 |
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| 基金项目： | 2014年山东省自然科学基金(ZR2014HP007) |
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| 摘 要： | 目的：检测皮肤基底细胞癌中真核细胞翻译起始因子4E(eIF4E)的表达。方法：采用免疫组化PV-9000法和Real-time PCR法分别检测20例皮肤基底细胞癌及20名健康皮肤组织中eIF4E蛋白及mRNA的表达。结果：基底细胞癌和健康皮肤组织中eIF4E蛋白MOD值分别为(0.198±0.031)和(0.096±0.015)，mRNA相对表达量分别为(2.32±1.00)和(1.24±0.17)，差异具有统计学意义(P<0.05)。结论：eIF4E可能参与皮肤肿瘤的发病过程。
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| 关 键 词： | 基底细胞癌 真核细胞翻译起始因子4E 免疫组化 实时荧光定量PCR |
Expression of eIF4E in basal cell carcinoma |
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| DENG Yue,LIU Haidong,ZHUANG Le,MA Weiyuan. Expression of eIF4E in basal cell carcinoma[J]. China Journal of Leprosy and Skin Diseases, 2016, 32(7): 388-390 |
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| Authors: | DENG Yue LIU Haidong ZHUANG Le MA Weiyuan |
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| Affiliation: | Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China |
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| Abstract: | Objective: To detect the expression of eukaryotic translation initiation factor 4E (eIF4E) in basal cell carcinoma ( BCC) . Methods:The protein and mRNA expressions of eIF4E were detected by PV-9000 immunohistochemistry and real-time PCR in 20 patients with basal cell carcinoma and 20 healthy con-trols. Results:The MODs in BCC and controls were 0.198±0.031 and 0.096±0.015 respectively and the ex-pression levels of mRNA were 2. 32 ± 1. 00 and 1. 24 ± 0. 17, with significant differences ( P<0. 05 ) . Conclusion:eIF4E may involve in the pathogenesis of BCC. |
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| Keywords: | basal cell carcinoma eIF4E immunohistochemistry RT-PCR |
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