| 银屑病患者外周血Th17/Th22细胞的表达 |
| |
| 引用本文： | 郭晓兰,李秀娟,杨文彪,黄芳仪. 银屑病患者外周血Th17/Th22细胞的表达[J]. 中国麻风皮肤病杂志, 2016, 32(7): 410-412 |
| |
| 作者姓名： | 郭晓兰 李秀娟 杨文彪 黄芳仪 |
| |
| 作者单位： | 1 江门市中心医院皮肤科,广东江门，5290302 江门市中心医院检验科,广东江门，529030 |
| |
| 基金项目： | 广东省医学科研基金资助(A2014782) |
| |
| 摘 要： | 目的:检测寻常性银屑病(PV)患者外周血Th17、 Th22的水平及相关因子IL-17、IL-22 、IL-6的血清水平。方法: PASI评分评估患者病情，采用流式细胞术检测40例PV患者和30例健康对照者外周血Th17和Th22细胞，ELISA法检测血清中IL-17、IL-22和IL-6水平。结果: PV患者Th17细胞及Th22细胞，血清IL-17、IL-22及血清IL-6的水平明显高于健康对照组比较（P均<0.01），且与PASI呈正相关（P＜0.05）。结论:Th17和Th22可能参与银屑病的发病。
|
| 关 键 词： | 银屑病 辅助性T细胞17 辅助性T细胞22 |
Expression of Th17 and Th22 in patients with psoriasis vulgaris |
| |
| GUO Xiaolan,LI Xiujuan,YANG Wenbiao,HUANG Fangyi. Expression of Th17 and Th22 in patients with psoriasis vulgaris[J]. China Journal of Leprosy and Skin Diseases, 2016, 32(7): 410-412 |
| |
| Authors: | GUO Xiaolan LI Xiujuan YANG Wenbiao HUANG Fangyi |
| |
| Affiliation: | 1. Department of Dermatology, the Central Hospital of Jiangmen, Jiangmen 529030, China;2. Department of Clinical Laboratory, the Central Hospital of Jiangmen, Jiangmen 529030, China |
| |
| Abstract: | Objective:To detect the level of Th17 and Th22 and the expression of related cytokines inclu-ding IL-17, IL-22 and IL-6 in of the patients with psoriasis vulgaris. Methods:The disease severity was e-valuated by PASI scores. The levels of peripheral blood Th17 and Th22 cells in 40 patients and 30 healthy controls were detected by flow cytometry. The levels of serum IL-17, IL-22 and IL-6 were detected by ELISA. Results:The levels of Th17, Th22, IL-17,IL-22 and IL-6 in the patients with psoriasis vulgaris were higher than those in healthy controls (P<0.01) and were positively correlated with PASI scores (P<0.05) . Conclusion:Th17 and Th22 cells may be involved in the pathogenesis of psoriasis vulgaris. |
| |
| Keywords: | psoriasis Th17 cell Th22 cell |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《中国麻风皮肤病杂志》浏览原始摘要信息 |
|
点击此处可从《中国麻风皮肤病杂志》下载免费的PDF全文 |
