A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis. |
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Authors: | Taral N Patel Mehdi H Shishehbor Deepak L Bhatt |
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Affiliation: | Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA. |
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Abstract: | Lipid lowering with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or 'statins' has dramatically reduced morbidity and mortality in patients with established cardiovascular disease. Recently, there have been multiple studies investigating the role of high-dose statin therapy with more aggressive lipid lowering in this setting. Concomitantly, there is increasing evidence implicating a role of inflammation in the pathogenesis of atherosclerosis. These high-dose statin trials and other studies have also provided a wealth of data suggesting that statins have anti-inflammatory and anti-oxidant properties that go beyond their lipid-lowering effects. In this review, we will provide a brief overview of recent, large-scale, randomized, placebo and active controlled trials of high-dose statin therapy in the setting of stable and unstable coronary artery disease and percutaneous coronary intervention. Further, we will discuss the evidence for effects of high-dose statin therapy on inflammation and C-reactive protein. |
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Keywords: | Coronary artery disease 3-hydroxy 3-methylglutaryl CoA reductase inhibitors (statins) C-reactive protein LDL |
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