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A review of high-dose statin therapy: targeting cholesterol and inflammation in atherosclerosis.
Authors:Taral N Patel  Mehdi H Shishehbor  Deepak L Bhatt
Affiliation:Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
Abstract:Lipid lowering with 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or 'statins' has dramatically reduced morbidity and mortality in patients with established cardiovascular disease. Recently, there have been multiple studies investigating the role of high-dose statin therapy with more aggressive lipid lowering in this setting. Concomitantly, there is increasing evidence implicating a role of inflammation in the pathogenesis of atherosclerosis. These high-dose statin trials and other studies have also provided a wealth of data suggesting that statins have anti-inflammatory and anti-oxidant properties that go beyond their lipid-lowering effects. In this review, we will provide a brief overview of recent, large-scale, randomized, placebo and active controlled trials of high-dose statin therapy in the setting of stable and unstable coronary artery disease and percutaneous coronary intervention. Further, we will discuss the evidence for effects of high-dose statin therapy on inflammation and C-reactive protein.
Keywords:Coronary artery disease    3-hydroxy 3-methylglutaryl CoA reductase inhibitors (statins)    C-reactive protein    LDL
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