妊娠甲状腺功能减退症研究的近期进展

妊娠甲状腺功能减退症(甲减)是近期内分泌学界关注的一个热点领域.本文重点介绍了美国内分泌学会2007年颁布的<妊娠和产后甲状腺功能异常处理的临床指南>提出的六点共识意见;妊娠时诊断甲状腺功能异常应当依据妊娠不同时期特异的甲状腺功能参考值,否则亚临床甲减可能被漏诊;妊娠相关的亚临床甲状腺异常有三种情况,即亚临床甲减、单纯低T4血症和单纯甲状腺过氧化物酶抗体(TPOAb)阳性,指南对这些异常的诊断提出了见解.

Recent progress in hypothyroidism during pregnancy

The research on hypothyroidism during pregnancy has been a hot field concerned by endocrinologists. This editorial highlights six aspects of consensus reached by American Endocrine Association in "Management of Thyroid Dysfunction during Pregnancy and Postpartum: An Endocrine Society Clinical Practice Guideline" in 2007. The appropriate diagnosis of thyroid dysfunction depends on gestational specific reference intervals of thyroid hormones, and otherwise the pregnant women with subclinical hypothyroidism will suffer from missed diagnosis. There are three types of subclinical thyroid disorders during pregnancy, namely subclinical hypothyroidism, hypothyroxinemia and simple positive thyroid peroxidase autoantibodies. The opinions on thediagnosis of these disorders are proposed in the context.