5-fluorouracil,adriamycin, and mitomycin-C (FAM) chemotherapy in advanced adenocarcinoma of the lung: comparison of two dosage schedules |
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| Authors: | W K Lam S Y So T M Kung M K Sham Mary Ip |
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| Institution: | (1) Department of Medicine, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong;(2) Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong |
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| Abstract: | Summary Fifty patients with inoperable adenocarcinoma of the lung were randomized in a prospective study to receive either standard doses or high doses of 5-fluorouracil, adriamycin, and mitomycin-C (FAM versus Hi-FAM). The response/stabilization rate was 32% for FAM and 34% for Hi-FAM (P>0.05), and the median survival was 27 weeks for FAM group and 24 weeks for Hi-FAM group (P>0.05). Myelotoxicity was mild in FAM, but moderate to severe in Hi-FAM. It is concluded that Hi-FAM did not yield a higher response rate or median survival compared with FAM, but caused significantly more severe myelotoxicity. |
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