| 干细胞对心力衰竭保护作用的研究进展 |
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| 引用本文： | 段伟. 干细胞对心力衰竭保护作用的研究进展[J]. 医学综述, 2010, 16(24) |
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| 作者姓名： | 段伟 |
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| 作者单位： | 中国人民解放军空军总医院心血管外科; |
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| 摘 要： | 干细胞不仅丰富了移植技术领域,而且是生物工程中理想的种子细胞,干细胞移植对心肌损伤及心力衰竭保护作用的可能机制为干细胞的定向分化作用、细胞间相互连接形成的"绑定"作用、干细胞的自/旁分泌功能等。近期研究干细胞移植机制偏向于旁分泌作用,主要通过分泌生物活性因子促进心脏内源性心肌前体细胞增殖,调控血管内皮细胞及平滑肌细胞增殖,抑制心肌纤维化来发挥阻止心室重构,改善心功能的作用。
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| 关 键 词： | 干细胞移植 心肌细胞 旁分泌 心肌损伤 心力衰竭 |
Advances in the Study of Stem Cells Based Protective Effect on Heart Failure |
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| DUAN Wei. Advances in the Study of Stem Cells Based Protective Effect on Heart Failure[J]. Medical Recapitulate, 2010, 16(24) |
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| Authors: | DUAN Wei |
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| Affiliation: | DUAN Wei,ZHANG Hong-chao.(Department of Cardiothoracic Surgery,Air Force General Hospital,China People's Liberation Army,Beijing 100142,China) |
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| Abstract: | Stem cells not only enriches transplantation technology,but also serves as desirable seed cells for bioengineering.The possible mechanisms of stem cells transplantation protective for myocardial damages and heart failure include directional differentiation,binding of cell-cell connection,and paracrine/autocrine function of stem cells.Previous studies on the mechanisms of stem cells transplantation highlight paracrine function.Stem cells can promote endogenous cardic precursor cell proliferation,regulate vas... |
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| Keywords: | Stem cell transplantation Cardic myocytes Paracrine Cardiac myocyte injury Heart failure |
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