Lack of seroconversion in a health care worker after polymerase chain reaction-documented acute hepatitis C resulting from a needlestick injury. |
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| Authors: | P Morand N Dutertre H Minazzi J Burnichon M Pernollet M Baud J P Zarski J M Seigneurin |
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| Affiliation: | Laboratoire de Virologie Structurale et Moléculaire, Faculté de Médecine, Centre Hospitalier Universitaire, Grenoble, France. PMorand@chu-grenoble.fr |
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| Abstract: | We present a case of documented acute hepatitis C that occurred in a health care worker who sustained a needlestick injury while caring for an individual who was infected with both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). According to the findings of third-generation serological assays performed during a follow-up of >1 year, the health care worker, who was treated with interferon-alpha (during weeks 2-6) and ribavirin (during weeks 5-9), did not develop antibodies against HCV, in spite of documentation of an HCV-specific T cell response. |
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