早期肠内营养联合肠屏障保护剂用于急性重症胰腺炎患者的治疗与护理

目的探讨鼻空肠管早期肠内营养联合肠屏障保护剂应用于急性重症胰腺炎（SAP）患者的治疗与护理。方法将62例SAP患者随机分为3组，A组给予常规治疗，B组在常规治疗基础上通过鼻空肠管给予早期肠内营养，C组在B组的基础上加用肠屏障保护剂。观察症状和体征、生化指标恢复正常的时间，血清白蛋白差值以及3组住院时间及总住院费用。结果B，C两组的症状和体症、生化指标恢复正常的时间、血清白蛋白、住院时间、住院费用等均优于A组，且C组的C 反应蛋白、白细胞计数恢复时间更优于B组，差异均有统计学意义；B，C两组的住院时间短于A组，住院费用少亦于A组，差异有统计学意义。结论应用鼻空肠管对SAP患者进行早期肠内营养联合肠屏障保护剂，可以改善患者的营养状况，促进早日恢复，缩短病程，减少总住院费用。

Application evaluation of early enteral nutrition by nasojejunal tube and intestine barrier protective agen on treatment of severe acute pancreatitis

Objective To evaluate the therapeutic effect of early enteral nutrition and intestine barrier protective agen on severe acute pancreatitis (SAP). Methods Six-two patients with severe acute pancreatitis were divided into group A, group B and group C randomly. Patients in group A were given conventional therapy, patients in group B were given enteral nutrition by nasogastric feeding, patients in group C were given enteral nutrition and intestine barrier protective agen by nasogastric feeding. The recovery time of symptom, physical sign and laboratory examination, the change of body weight and serum-albumin, and the length of stay and the whole cost of hospitalization were compared between groups. Results There were significantly differences between A and B、C groups in the recovery time of symptom, physical sign and laboratory examination, the cost of hospitalization and the length of stay (P<0.05). There were significantly differences between B and C group in the recovery time of C-reactive Protein and White Blood Cell (P<0.05). And there were significantlydifferences between between A and B、C groups in the length of stay and the whole cost of hospitalization(P<0.05). Conclusions Early enteral nutrition and intestine barrier protective agen on treatment of severe acute pancreatitis can improve nutriture, improve the patients' recovery, shorten length of stay and reduce the hospitalization cost.