蛋白水解诱导因子在食管鳞状细胞癌中的表达

目的：研究蛋白水解诱导因子（proteolysis-inducing factor，PIF）在食管鳞状细胞癌中的表达及意义。方法：应用免疫组化方法，检测PIF在107例食管鳞状细胞癌病人癌组织以及其中35例癌旁正常组织以及8例食管良性疾病标本中的表达情况，并探讨PIF表达与食管癌临床分期、肿瘤分化程度的关系。结果：食管鳞状细胞癌组织中存在PIF表达，其表达与食管良性疾病对照组中的表达差异有统计学意义（P〈0．05），肿瘤组织中表达PIF的个体其癌旁正常组织中亦有PIF表达，PIF表达在肿瘤分化、是否侵及浆膜层、有无淋巴结转移和肿瘤分期中的差异无统计学显著性（P〉0．05）。结论：食管鳞状细胞癌组织中存在PIF表达，其表达与肿瘤分化、是否侵及浆膜层、有无淋巴结转移和肿瘤分期无关。

Expression of proteolysis inducing factor in esophageal squamous cell carcinoma

Objective ：To study the expression and significance of proteolysis - inducing factor（PIF）. Methods： PIF was tested in the tumor tissue of esophageal squamous cell carcinoma by immunohistochemistry. Results： The tumor tissue of esophageal squamous cell carcinoma expressed PIF, and its expression had statistical signaficance with no tumor control（ P 〈 0. 01 ）. Its expression between the tissue of esophageal squamous cell carcinoma and its adjacent normal tissue had no signaficance, and no relation with clinical stage, differentiation of esophageal squamous cell carcinoma, lymphatic metastasis, invading. Conclusion： Tumor tissue of esophageal squamous cell carcinoma expressed PIF,its expression had no relation with tissue differentian, lymphatic metastasis, invading the placenta percreta or cancer clinical staging.