Anti-immunoglobulin antibody detection in adjuvant arthritis by an ELISA technique |
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| Authors: | M Castell M C Castellote J Queralt |
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| Affiliation: | 1. School of Mechanical and Precision Instrument Engineering, Xi''an University of Technology, Xi''an 710048, China;2. Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System, School of Mechanical Engineering, Xi''an Jiaotong University, Xi''an 710049, China |
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| Abstract: | Sprague-Dawley rats, injected in the hind paw with heat-killed mycobacteria dispersed in oil, develop a severe polyarthritis. In this paper, we detected and quantified by a micro-ELISA technique autoantibodies against immunoglobulins in rats with adjuvant arthritis. Increased total anti-immunoglobulin antibodies levels were found from 3 days after induction and remained elevated until day 42. IgG anti-immunoglobulin antibodies in arthritic animals were significantly elevated during days 35-42. These results show that alterations in the humoral immune response (synthesis of anti-immunoglobulin antibodies) are present in adjuvant arthritis as they are in human rheumatoid arthritis. |
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