苯那普利拉对高血压所致左心室重构及舒张顺应性变化的影响

目的：观察苯那普利拉（洛汀新）对高血压所致左心室重构及舒张顺应性变化的影响。方法：５０例高血压病伴左心室肥厚的患者，Ⅰ组（治疗组）３０例，给予洛汀新１０ ｍ ｇ／ｄ，Ⅱ组（对照组）２０例，给予硝苯吡啶３０ ｍ ｇ／ｄ，治疗６个月后，测定左心室室壁厚度及左心室舒张功能的变化。结果：治疗组血压由２３９４±４７９／１４２５±１３３ ｋ Ｐａ 降至１８３５±２１８／１２２１±１３４ ｋ Ｐａ（ Ｐ＜ ００１），左室后壁厚度由１２５±２５ ｍ ｍ 降至１１２±２３ ｍ ｍ ，室间隔厚度由１２６±２８ ｍ ｍ 降至１１０±２２ ｍ ｍ （ Ｐ均＜ ００１），二尖瓣前叶 Ｅ Ｆ 斜率（ Ｅ Ｆ Ｖ）由１２０±２３ ｍ ｍ ／ｓ 升至１５０±４０ ｍ ｍ ／ｓ， 左室舒张末压（ Ｌ Ｖ Ｅ Ｄ Ｐ）由１５７±０４１ ｋ Ｐａ 降至１３５±０２０ ｋ Ｐａ（ Ｐ 均＜ ００１）。而对照组，除血压有显著下降外（ Ｐ＜ ００１），其他指标均无显著变化（ Ｐ 均＞ ００５）。结论：洛汀新不但有良好的降压效果，而且可逆转左室肥厚，抑制心肌重构，改善左室舒张顺应性。

Effects of Benazepril on diastolic compliance and reconstruction of left ventricle induced by hypertension

Objective:To observe the effects of benazepril on diastolic compliance and reconstruction of left ventricle due to hypertension.Methods:Fifty cases were all hypertension coexisting left ventricle hypertrophy that were randomly divided into two groups.Thirty cases in Ⅰ (treated) group were treated with benazepril,10 mg per day;Twenty cases in Ⅱ (control) group,treated by nifedipini,30 mg per day.After 6 months,the thickness of left ventricle wall and the diastolic compliance of left ventricle were determined.Results:The results showed:arterial pressure descended from 23 94±4 79/14 25±1 33 kPa to 18 35±2 18/12 21±1 34 kPa ( P <0 01);the tihckness of left ventricle posterior wall, from 12 5±2 5 mm to 11 2±2 3 mm ( P <0 01);the thickness of ventricular septum from 12 6±2 8 mm down to 11 0±2 2 mm ( P <0 01);early diastolic velocity of mitral valve rose from 120 ±23 mm/s to 150±40 mm/s ( P <0 01);the end diastolic pressure of left ventricle descended from 1.57±0.41 kPa to 1 35±0 20 kPa ( P <0 01) in group Ⅰ,while,there were not significant changes except significantly descended in group Ⅱ.Conclusion:Benazepril can not only descend the arterial pressure,but also reverse the left ventricle hypertrophy,inhibit the reconstruction and improve the diastolic compliance of left ventricle.