CT征象联合免疫组织化学指标鉴别诊断肺癌的研究

目的研究肺癌环氧化酶2(COX-2)、血管内皮生长因子(VEGF)、微血管密度(MVD)表达与CT征象及增强表现之间的相关性。资料与方法对经病理证实的25例肺癌及35例肺良性病变行CT扫描,并应用P-V法对其病理标本进行免疫组织化学分析,研究COX-2、VEGF、MVD表达水平与CT征象及增强表现之间的相关性。结果肺癌组COX-2、VEGF、MVD表达水平明显高于肺良性病变组;COX-2、VEGF、MVD表达与某些CT征象及增强表现密切相关。结论COX-2、VEGF、MVD可作为临床评价肿瘤发展,估计肿瘤预后的重要分子生物学指征。某些CT征象及增强表现可以反映肺癌的血供特点,可根据它们来推测肿瘤的侵袭、转移及预后情况。

The Research of Combining CT Findings and Immunohistochemistry Signs to Diagnose Lung Cancer

Objective To discuss the relationship between the expression of COX 2,VEGF,MVD and the CT findings,enhancement appearances of lung cancer.Materials and Methods Dynamic CT scans were taken respectively in 35 patients with benign disease and 25 patients with lung cancer confirmed pathologically.The PV method was used to detect the expression of COX 2,VEGF and MVD in all cases to analyze the relationship between the CT findings,enhancement appearances and expression of the three immunochemical indexes.Results Expression level of COX 2,VEGF and MVD in lung carcinoma group was higher than that in the lung benign disease group,expression level of COX 2,VEGF and MVD was related to some of the CT findings,enhancement appearances of the lung cancer.Conclusion COX 2,VEGF and MVD may be important molecular biology predictors in the early diagnosis of lung cancer and can evaluate prognosis of patients with lung cancer.Some CT findings and dynamic CT enhancement appearances can reflect the vascularity characteristic of lung cancer,and also predict the involvement,metastasis and prognosis of lung carcinoma.