| 肝次全切除对二乙基亚硝胺诱发大鼠肝硬变及肝细胞癌的影响 |
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| 引用本文： | 罗德元,王朝俊,邓士林. 肝次全切除对二乙基亚硝胺诱发大鼠肝硬变及肝细胞癌的影响[J]. 四川大学学报(医学版), 1987, 0(3) |
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| 作者姓名： | 罗德元 王朝俊 邓士林 |
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| 作者单位： | 华西医大肿瘤研究所(罗德元，王朝俊)，华西医大肿瘤研究所(邓士林) |
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| 摘 要： | 作者将大鼠作肝次全(3/4)切除后,腹腔注射DENA28mg/kg,每周一次,与不切肝组动物相比,寿命缩短,患肝硬变、肝细胞异型性增生及肝细胞癌的大鼠发生数明显增多,病变程度加重,诱发病变的时间缩短。
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| 关 键 词： | 肝次全(3/4)切除术 二乙基亚硝胺 大鼠 肝硬变 肝细胞癌 |
EFFECT OF SUBTOTAL HEPATECTOMY IN RATS ON INDUCTION OF CIRRHOSIS OF LIVER AND HEPATOCELLULAR CARCINOMA BY DIETHYLNITROSAMINE |
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| Luo Deyuan,Wang Chaojun,Deng Shilin Institute of Cancer Research. EFFECT OF SUBTOTAL HEPATECTOMY IN RATS ON INDUCTION OF CIRRHOSIS OF LIVER AND HEPATOCELLULAR CARCINOMA BY DIETHYLNITROSAMINE[J]. Journal of Sichuan University. Medical science edition, 1987, 0(3) |
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| Authors: | Luo Deyuan Wang Chaojun Deng Shilin Institute of Cancer Research |
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| Affiliation: | Luo Deyuan;Wang Chaojun;Deng Shilin Institute of Cancer Research |
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| Abstract: | Rats were subtotal (3/4) hepatectomized(25 rats) and subsequently diethylnitrosa-mine(DENA)was applied i. p. (28 mg DENA/kg/week).Compared with a non-hepatecto-mized group (18 rats), the mean survivaltime was shortened.A higher incidence ofcirrhosis of the liver, atypical hyperplasiaof the liver cells and hepatomas was foundin the hepatectomized group. In themeantime, the grades of the pathologicalchanges were enhanced, and the inductiveperiods also shortened,in the hepatectomizedgroup. |
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| Keywords: | Diethylnitrosamine Rat Subtotal hepatectomy Cirrhosis of liver Hepatoma |
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