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| 中药延缓慢性肾功能衰竭进展的机制和效果 | |
| 引用本文： | 冯青,万毅刚,蒋春明,王朝俊,魏晴雪,赵青,姚建. 中药延缓慢性肾功能衰竭进展的机制和效果[J]. 中国中药杂志, 2011, 36(9): 1122-1128 |
| 作者姓名： | 冯青 万毅刚 蒋春明 王朝俊 魏晴雪 赵青 姚建 |
| 作者单位： | 1. 南京中医药大学,中西医结合鼓楼临床医学院,江苏,南京,210008 2. 南京大学,医学院,附属鼓楼医院,江苏,南京,210008 3. 日本山梨大学,研究生院,医学工学综合研究部分子信号教研室,日本,山梨,409-3898 |
| 基金项目： | 南京市医学科技发展项目(YKK08058) |
| 摘 要： | 中药延缓慢性肾功能衰竭(chronic renal failure,CRF)进展的机制主要是指中药改善肾小球硬化和肾间质纤维化的作用,譬如,通过影响肾小球血流动力,减轻足细胞损伤,抑制转化生长因子-β表达,调整脂质代谢紊乱来改善肾小球硬化;通过减轻巨噬细胞浸润,抑制肾小管上皮细胞转分化,降低尿蛋白毒性来改善肾间质纤维化等.中药延缓CRF进展的临床效果主要体现在改善肾功能和某些并发症等方面,其治疗方法包括中药复方口服、中药保留灌肠、中药复方口服联合中药保留灌肠以及结肠透析联合中药保留灌肠等.另外,对于晚期CRF患者所出现的钙/磷代谢失衡、微炎症状态以及尿毒症毒素蓄积,中药也有一定的改善作用. |
| 关 键 词： | 慢性肾功能衰竭 中药 药理机制 临床疗效 |
| 收稿时间： | 2010-10-29 |
Mechanisms and effects of Chinese herbal medicine delaying progression of chronic renal failure |
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| FENG Qing,WAN Yigang,JIANG Chunming,WANG Chaojun,WEI Qingxue,ZHAO Qing and YAO Jian. Mechanisms and effects of Chinese herbal medicine delaying progression of chronic renal failure[J]. China Journal of Chinese Materia Medica, 2011, 36(9): 1122-1128 | |
| Authors: | FENG Qing WAN Yigang JIANG Chunming WANG Chaojun WEI Qingxue ZHAO Qing YAO Jian |
| Affiliation: | Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210008, China;Department of Molecular Signaling Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi 409-3898, Japan |
| Abstract: | In this review,firstly,it has been discussed the mechanisms of Chinese herbal medicine ameliorating glomerulosclerosis and renal interstitial fibrosis during the progression of chronic renal failure (CRF) by improving glomerular hemodynamics turbulence, podocyte injury, transforming growth factor (TGF)-beta over-expression, hyperlipidemia, macrophage infiltration, tubular epithelial myofibroblast transdifferentiation, and nephrotoxicity of proteinuria. Secondly,it has been reported the clinical effects of Chinese herbal medicine improving renal function and some clinical complications in the patients with progressive CRF through various treatments including oral administration or coloclysis of Chinese herbal medicine, oral administration combined with coloclysis of Chinese herbal medicine, and colonic dialysis combined with coloclysis of Chinese herbal medicine. Finally,it has been reviewed the beneficial influences of Chinese herbal medicine on metabolic dysequilibrium of calcium and phosphonium, microinflammatory state, and uremic toxins in patients with uremia. |
| Keywords: | chronic renal failure(CRF) Chinese herbal medicine mechanism clinical effect |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |