异基因骨髓移植合并播散性毛霉菌病国内首例报告并文献复习

目的 提高对恶性血液病并发播散性毛霉菌病的认识。方法 报告１例异基因骨髓移植术（ａｌｌｏＢＭＴ）合并播散性毛霉病的诊断和治疗过程，并进行文献复习。结果和结论 ①毛霉菌病的特征是发病急，进展快，死亡率极高，感染部位多样，易播散至肺和脑；②二性霉素Ｂ（ＡＭＢ）是治疗首选药物；③早期、足量、长疗程应用是提高生存率的关键。

Disseminated mucormycosis after allogeneic bone marrow transplantation: the first domestic report with a literature review

Objective To better understand the hematological malignancies complicated by disseminated mucormycosis.?Method The detailed data of a patient with disseminated mucormycosis after allogeneic bone marrow transplantation(allo BMT) were described, and the diagnosis and clinical intervention of the disease were reviewed.?Results and Conclusions The disseminated mucormycosis in BMT is characterized by acute onset, rapid progress and extremely high mortality, occurring in multiple varied infectious foci, and often spread to the lungs and the brain. Amphotericin B(AMB) should be the first choice for treatment, and early treatment, sufficient dosage and prolonged use of the drug are the keys to get a higher survival rate.