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Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line

Authors:	Lu?Xie,Brian?K?Law,Mary?E?Aakre,Mary?Edgerton,Yu?Shyr,Neil?A?Bhowmick,Harold?L?Moses author-information" > author-information__contact u-icon-before" > mailto:hal.moses@vanderbilt.edu" title=" hal.moses@vanderbilt.edu" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author

Affiliation:	(1) Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA;(2) Department of Pathology and Preventive Medicine, Vanderbilt University, Nashville, Tennessee, USA;(3) Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee, USA;

Abstract:	Background Transforming growth factor beta (TGF-β) plays an essential role in a wide array of cellular processes. The most well studied TGF-β response in normal epithelial cells is growth inhibition. In some cell types, TGF-β induces an epithelial to mesenchymal transition (EMT). NMuMG is a nontransformed mouse mammary gland epithelial cell line that exhibits both a growth inhibitory response and an EMT response to TGF-β, rendering NMuMG cells a good model system for studying these TGF-β effects.

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