| 胃癌中血小板衍生内皮细胞生长因子的表达与微血管生成 |
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| 引用本文： | 葛敦钧,胡希宏,胡立明. 胃癌中血小板衍生内皮细胞生长因子的表达与微血管生成[J]. 中华普通外科学文献(电子版), 2008, 2(4): 13-16 |
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| 作者姓名： | 葛敦钧 胡希宏 胡立明 |
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| 作者单位： | 浙江省东阳市人民医院普外科,东阳,322100 |
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| 摘 要： | 目的研究探讨胃癌组织中血小板衍生内皮细胞生长因子（PD-ECGF）的表达及微血管密度（MVD）与胃癌生物学行为和血管生成的关系。方法应用免疫组化Elivision^TM法检测52份胃癌组织中PD—ECGF、CD34的表达并测定MVD，回顾分析胃癌患者的临床病理资料。结果胃癌组织中PD—ECGF的表达率为59．62％，平均MVD为72．60±16．87；伴有淋巴结转移组、侵及浆膜或浆膜外组的PD—ECGF的阳性率及MVD显著高于无淋巴结转移组、浸润深度未达浆膜层组，且Ⅲ期和Ⅳ期组的MVD高于Ⅰ期和Ⅱ期组；PD—ECGF阳性组的MVD高于阴性组。结论PD—ECGF参与了胃癌的浸润和转移及血管生成，PD—ECGF作为肿瘤抗血管治疗的靶点具有一定的价值。
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| 关 键 词： | 胃癌 PD—ECGF 微血管密度 血管生成 |
The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma |
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| GE Dun-jun,HU Xi-hong,HU Li-ming. The expression of platelet-derived endothelial cell growth factor and microvascular density in human gastric carcinoma[J]. Chinese Journal of General Surgery(Electronic Version), 2008, 2(4): 13-16 |
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| Authors: | GE Dun-jun HU Xi-hong HU Li-ming |
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| Affiliation: | .( The People＇s Hospital of DongYang, DongYang 322100,China) |
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| Abstract: | Objective To explore the relationship between the expression of platelet-derived endothelial cell growth factor(PD-ECGF) together with microvascular density(MVD) and biological behaviour and tumor angiogenesis in gastric carcinoma.Methods ElivisionTM immunohistochemical method was performed to detect the expression of PD-ECGF and CD34,evaluated the value of MVD in fifty-two gastric carcinoma specimens.Clinicopathologic materials of patients were assayed retrospectively.Results The positive expression of PD-... |
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| Keywords: | PD-ECGF |
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